Evidence map›Paper›PMID 26541688›Full record

ArticleThe British journal of psychiatry : the journal of mental science2016

Visual cortical excitability in dementia with Lewy bodies.

John-Paul Taylor, Michael Firbank, John T O'Brien

Open access · hybridAbstract read
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Visual dysfunction in dementia with Lewy bodies.Current neurology and neuroscience reports · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

John-Paul TaylorJohn-Paul Taylor, MBBS, PhD, MRCPsych, Michael Firbank, PhD, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne; John T. O'Brien, MD, FRCPsych, Department of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK john-paul.taylor@ncl.ac.uk.
Michael FirbankJohn-Paul Taylor, MBBS, PhD, MRCPsych, Michael Firbank, PhD, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne; John T. O'Brien, MD, FRCPsych, Department of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
John T O'BrienJohn-Paul Taylor, MBBS, PhD, MRCPsych, Michael Firbank, PhD, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne; John T. O'Brien, MD, FRCPsych, Department of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
University of Cambridge · GB

Funding

Wellcome Trust WT088441MA
6 · The paper itself

Abstract

Alterations in the visual system may underlie visual hallucinations in dementia with Lewy bodies (DLB). However, cortical excitability as measured by transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) activation of lower visual areas (V1-3) to visual stimuli appear normal in DLB. We explored the relationship between TMS-determined phosphene threshold and fMRI-related visual activation and found a positive relationship between the two in controls but a negative one in DLB. This double dissociation suggests a loss of inhibition in the visual system in DLB, which may predispose individuals to visual dysfunction and visual hallucinations.

Indexed as

Cortical ExcitabilityHallucinationsHumansLewy Body DiseaseMagnetic Resonance ImagingPhosphenesTranscranial Magnetic StimulationVisual CortexVisual Perception

Identifiers

PMID26541688
PMCPMC4853644
OpenAlexW1901009179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.