ArticlePsychological medicine2016
Divergent subcortical activity for distinct executive functions: stopping and shifting in obsessive compulsive disorder.
Article in Psychological medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies.NeuroImage. Clinical · 2022Pooled it
- Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.Biological psychiatry · 2019Pooled it
- Multimodal network localization of brain abnormalities and neuromodulation target identification in obsessive-compulsive disorder.Scientific reports · 2026Article
- Frontostriatal salience network expands as executive networks contract in Obsessive-Compulsive Disorder.bioRxiv : the preprint server for biology · 2025Article
- N-back task revisited: Comparing the neural correlates of updating and interference control.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neural Correlates of Executive Functioning in Anorexia Nervosa and Obsessive-Compulsive Disorder.Frontiers in human neuroscience · 2022Review
- Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder.Frontiers in psychiatry · 2022Article
- Functional Brain Imaging and OCD.Current topics in behavioral neurosciences · 2021Review
- Gray Matter Abnormalities of Orbitofrontal Cortex and Striatum in Drug-Naïve Adult Patients With Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2021Article
- Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder.Neural plasticity · 2021Article
- Classification of Obsessive-Compulsive Disorder Using Distance Correlation on Resting-State Functional MRI Images.Frontiers in neuroinformatics · 2021Article
- Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2020Article
- Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits.Frontiers in psychology · 2020Article
- Investigating the predictive value of different resting-state functional MRI parameters in obsessive-compulsive disorder.Translational psychiatry · 2019Article
- Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder.Psychological medicine · 2017Article
- The Flexibility Scale: Development and Preliminary Validation of a Cognitive Flexibility Measure in Children with Autism Spectrum Disorders.Journal of autism and developmental disorders · 2017Article
- Real-time functional magnetic resonance imaging in obsessive-compulsive disorder.Neuropsychiatric disease and treatment · 2017Review
- Article
- Brain structural and functional impairment network localization in obsessive-compulsive disorder.Journal of psychiatry & neuroscience : JPNArticle
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7 authors.
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Abstract
backgroundThere is evidence of executive function impairment in obsessive compulsive disorder (OCD) that potentially contributes to symptom development and maintenance. Nevertheless, the precise nature of these executive impairments and their neural basis remains to be defined.
methodWe compared stopping and shifting, two key executive functions previously implicated in OCD, in the same task using functional magnetic resonance imaging, in patients with virtually no co-morbidities and age-, verbal IQ- and gender-matched healthy volunteers. The combined task allowed direct comparison of neural activity in stopping and shifting independent of patient sample characteristics and state variables such as arousal, learning, or current symptom expression.
resultsBoth OCD patients and controls exhibited right inferior frontal cortex activation during stopping, and left inferior parietal cortex activation during shifting. However, widespread under-activation across frontal-parietal areas was found in OCD patients compared to controls for shifting but not stopping. Conservative, whole-brain analyses also indicated marked divergent abnormal activation in OCD in the caudate and thalamus for these two cognitive functions, with stopping-related over-activation contrasting with shift-related under-activation.
conclusionsOCD is associated with selective components of executive function, which engage similar common elements of cortico-striatal regions in different abnormal ways. The results implicate altered neural activation of subcortical origin in executive function abnormalities in OCD that are dependent on the precise cognitive and contextual requirements, informing current theories of symptom expression.
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