Evidence map›Paper›PMID 26541392›Full record

Trial reportJournal of the American Heart Association2015

Time-Course Analysis of Flow Mediated Dilation for the Evaluation of Endothelial Function After a High-Fat Meal in African Americans.

Alejandro Marinos, Jorge E Celedonio, Claudia E Ramirez, JoAnn Gottlieb, Alfredo Gamboa, Nian Hui, Chang Yu, C Michael Stein, Italo Biaggioni, Cyndya A Shibao

2 registry-linked trialsOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01334554 phase1 / phase2completednot on this map

Effect of Sildenafil Citrate on Insulin Resistance and Endothelial Function in Obese African American Women

TypeinterventionalSponsorVanderbilt University Medical CenterRan2011 to 2013Enrolled46ConditionsMetabolic Syndrome, ObesityArmsSildenafil, Placebo
NCT02126735 completednot on this map

Metabolic and Cardiovascular Impact of CD36 Deficiency in African Americans

TypeobservationalSponsorVanderbilt University Medical CenterRan2013 to 2016Enrolled21ConditionsObesity
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. High-sodium diet does not worsen endothelial function in female patients with postural tachycardia syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Trial
  4. Trial
  5. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Alejandro MarinosDepartment of Internal Medicine, William Beaumont Hospital Internal Medicine, Royal Oak, MI (A.M.).
Jorge E CeledonioDepartment of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN (J.E.C., C.E.R., A.G., M.S., I.B., C.A.S.).
Claudia E RamirezDepartment of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN (J.E.C., C.E.R., A.G., M.S., I.B., C.A.S.).
JoAnn GottliebClinical Research Center, Vanderbilt University School of Medicine, Nashville, TN (J.A.G.).
Alfredo GamboaDepartment of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN (J.E.C., C.E.R., A.G., M.S., I.B., C.A.S.).
Nian HuiDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN (N.H., C.Y.).
Chang YuDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN (N.H., C.Y.).
C Michael SteinDepartment of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN (J.E.C., C.E.R., A.G., M.S., I.B., C.A.S.).
Italo BiaggioniDepartment of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN (J.E.C., C.E.R., A.G., M.S., I.B., C.A.S.).
Cyndya A ShibaoDepartment of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN (J.E.C., C.E.R., A.G., M.S., I.B., C.A.S.).
Vanderbilt University · USBeaumont Hospital, Royal Oak · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Structural genomics of norepinephrine transportersP01HL056693 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROBERTSON, DAVID HERLIE · 1997 to 2016
$30.8M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
TRANSGENIC MOUSE/ ES CELL SHARES RESOURCESP60DK020593 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 1986 to 2011
$28.1M
Training CoreU54NS065736 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 2009 to 2018
$11.6M
Aldosterone and Sodium Regulation in Postural Tachycardia SyndromeR01HL102387 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GARLAND, EMILY M · 2010 to 2014
$2.1M
Obesity hypertension in African American women: Neuro-metabolic mechanismsK23HL103976 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHIBAO, CYNDYA ADRIANA · 2010 to 2014
$760k
Sympathetic Nervous System and Nitric Oxide in Obesity Associated HypertensionK23HL095905 · NHLBI · VANDERBILT UNIVERSITY · PI GAMBOA, ALFREDO · 2010 to 2014
$754k
NCRR NIH HHS UL1 RR024975NHLBI NIH HHS K23 HL103976NHLBI NIH HHS P01 HL056693NHLBI NIH HHS R01 HL102387NIDDK NIH HHS DK20593NIDDK NIH HHS P30 DK020593NINDS NIH HHS U54 NS065736
6 · The paper itself

Abstract

backgroundFlow-mediated dilation (FMD) is used to assess endothelial function through changes in vascular diameter after hyperemia. High-fat meal (HFM) has been shown to induce endothelial dysfunction; recent studies, however, reported conflicting results in obese African American women (AAW). Differences in the method used to analyze FMD may explain these discrepancies. METHODS AND

resultsIn protocol 1, we assessed the time course of FMD and compared the repeatability of FMD using the individual maximum peak dilation (FMDpeak) and the dilation at 60 seconds (FMD60). Sixteen AAW (age, 42±10.4 years; body mass index [BMI], 39±5.8 kg/m(2)) were studied on 2 occasions, 4 weeks apart, under fasting conditions (study 1 and study 2). In protocol 2, we used the most repeatable measurement from protocol 1 to assess changes in endothelial function after an HFM in 17 AAW (agen 42±11.1 years; BMIn 38±5.6 kg/m(2)). We found that FMDpeak was the most repeatable measurement (N=16; study 1, 5.31±3.12% and study 2, 5.80±2.91%; r=0.94). After an HFM, the baseline brachial artery diameter significantly increased at 2 hours (0.10 mm; 95% confidence interval [CI], 0.01-0.18; P=0.03) and at 4 hours (0.17 mm; 95% CI, 0.09-0.25; P<0.001). At 2 hours, the FMDpeak decreased compared with pre-HFM (-1.76; 95% CI, -3.55-0.02; P≤0.05).

conclusionsThe individual's maximum peak dilation after hyperemia is the most consistent measure to assess the effect of an HFM on endothelial function. Endothelial dysfunction occurred at 2 hours after an HFM in AAW. CLINICAL

trial registrationURL: https://clinicaltrials.gov/ Unique identifiers: NCT01334554 and NCT02126735.

Indexed as

Black or African AmericanMealsVasodilationAdultBody Mass IndexBrachial ArteryDiet, High-FatEndothelium, VascularFemaleHumansHyperemiaMaleMiddle AgedObesityPredictive Value of TestsRegional Blood FlowAfrican Americanendothelial dysfunctionhigh fat dietobesity

Identifiers

PMID26541392
PMCPMC4845211
OpenAlexW2124486724

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.