Evidence map›Paper›PMID 26541319›Full record

ArticleArchives of biochemistry and biophysics2015

Relative contributions of L-FABP, SCP-2/SCP-x, or both to hepatic biliary phenotype of female mice.

Gregory G Martin, Danilo Landrock, Kerstin K Landrock, Philip N Howles, Barbara P Atshaves, Ann B Kier, Friedhelm Schroeder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gregory G MartinDepartment of Physiology and Pharmacology, Texas A&M University, College Station, TX 77843-4466, USA.
Danilo LandrockDepartment of Pathobiology, Texas A&M University, College Station, TX 77843-4467, USA.
Kerstin K LandrockDepartment of Physiology and Pharmacology, Texas A&M University, College Station, TX 77843-4466, USA.
Philip N HowlesDepartment of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45219, USA.
Barbara P AtshavesDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
Ann B KierDepartment of Pathobiology, Texas A&M University, College Station, TX 77843-4467, USA.
Friedhelm SchroederDepartment of Physiology and Pharmacology, Texas A&M University, College Station, TX 77843-4466, USA. Electronic address: fschroeder@cvm.tamu.edu.
Texas A&M University · USMichigan State University · USUniversity of Cincinnati · US

Funding

LIPID, LIPOPROTEIN, AND GLUCOSE METABOLISM COREU24DK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2001 to 2015
$12.9M
FATTY ACID BINDING PROTEINS-LIGAND SPECIFICITYR01DK041402 · NIDDK · UNIVERSITY OF CINCINNATI · PI SCHROEDER, FRIEDHELM · 1989 to 2010
$4.4M
Carboxyl Ester Lipase Affects Hepatic HDL MetabolismR01HL078900 · NHLBI · UNIVERSITY OF CINCINNATI · PI HOWLES, PHILIP N · 2006 to 2009
$1.6M
Lipid droplet domains foster lipid storageR01DK070965 · NIDDK · TEXAS A&M AGRILIFE RESEARCH · PI ATSHAVES, BARBARA P · 2007 to 2011
$1.4M
Lipid droplet domains foster lipid storageR56DK070965 · NIDDK · TEXAS A&M UNIVERSITY SYSTEM · PI ATSHAVES, BARBARA P · 2005 to 2005
$73k
NHLBI NIH HHS HL078900NHLBI NIH HHS R01 HL078900NIDDK NIH HHS DK41402NIDDK NIH HHS DK70965NIDDK NIH HHS R01 DK041402NIDDK NIH HHS R01 DK070965NIDDK NIH HHS R56 DK070965NIDDK NIH HHS U24 DK059630
6 · The paper itself

Abstract

Both sterol carrier protein-2/sterol carrier protein-x (SCP-2/SCP-x) and liver fatty acid binding protein (L-FABP) have been proposed to function in hepatobiliary bile acid metabolism/accumulation. To begin to address this issue, the impact of ablating L-FABP (LKO) or SCP-2/SCP-x (DKO) individually or both together (TKO) was examined in female mice. Biliary bile acid levels were decreased in LKO, DKO, and TKO mice; however, hepatic bile acid concentration was decreased in LKO mice only. In contrast, biliary phospholipid level was decreased only in TKO mice, while biliary cholesterol levels were unaltered regardless of phenotype. The loss of either or both genes increased hepatic expression of the major bile acid synthetic enzymes (CYP7A1 and/or CYP27A1). Loss of L-FABP and/or SCP-2/SCP-x genes significantly altered the molecular composition of biliary bile acids, but not the proportion of conjugated/unconjugated bile acids or overall bile acid hydrophobicity index. These data suggested that L-FABP was more important in hepatic retention of bile acids, while SCP-2/SCP-x more broadly affected biliary bile acid and phospholipid levels.

Indexed as

AnimalsBile Acids and SaltsBiliary TractCarrier ProteinsCholesterolFatty Acid-Binding ProteinsFemaleLiverMiceMice, Inbred C57BLMice, KnockoutPhenotypePhospholipidsBile Acids and SaltsCarrier ProteinsCholesterolFabp1 protein, mouseFatty Acid-Binding ProteinsPhospholipidssterol carrier proteinsBile acidGene ablationL-FABPSCP-2SCP-xSexual dimorphism

Identifiers

PMID26541319
PMCPMC4683591
OpenAlexW2197524664

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.