ReviewThe journal of physiological sciences : JPS2016
Non-genomic regulation and disruption of spermatozoal in vitro hyperactivation by oviductal hormones.
Review in The journal of physiological sciences : JPS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Regulation of spermatozoal capacitation by serotonin.The Journal of reproduction and development · 2026Review
- Interactions among progesterone, estradiol, and γ-aminobutyric acid in rat spermatozoal hyperactivation.The Journal of reproduction and development · 2026Article
- Tryptophan promotes sperm hyperactivation in hamsters via 5-hydroxytryptamine biosynthesis within sperm.The Journal of reproduction and development · 2025Article
- Influences of 5-hydroxytriptamine on sperm hyperactivation and in vitro fertility in rats.The Journal of reproduction and development · 2025Article
- Boar Sperm Motility Assessment Using Computer-Assisted Sperm Analysis: Current Practices, Limitations, and Methodological Challenges.Animals : an open access journal from MDPI · 2025Review
- Progesterone and estradiol regulate sperm hyperactivation and in vitro fertilization success in mice.The Journal of reproduction and development · 2024Article
- Enhancement of rat spermatozoal hyperactivation by progesterone.The Journal of reproduction and development · 2023Article
- Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice.The Journal of reproduction and development · 2023Article
- Hamster Sperm Possess Functional NaInternational journal of molecular sciences · 2023Article
- Pre-Treatment of Swine Oviductal Epithelial Cells with Progesterone Increases the Sperm Fertilizing Ability in an IVF Model.Animals : an open access journal from MDPI · 2022Article
- An interactive analysis of the mouse oviductal miRNA profiles.Frontiers in cell and developmental biology · 2022Article
- Serotonergic signals enhanced hamster sperm hyperactivation.The Journal of reproduction and development · 2021Article
- Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice.The Journal of reproduction and development · 2019Article
- Effect ofReproductive medicine and biology · 2019Article
- Flagellar hyperactivation of bull and boar spermatozoa.Reproductive medicine and biology · 2018Review
- γ-Aminobutyric acid suppresses enhancement of hamster sperm hyperactivation by 5-hydroxytryptamine.The Journal of reproduction and development · 2017Article
- Effects of aging and oviductal hormones on testes, epididymides, and sperm of hamster.Reproductive medicine and biologyArticle
- Influences of 5-Hydroxytryptamine Receptor Agonists on Spermatozoal Hyperactivation and In Vitro Fertilization Success in Mice.Reproductive medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During capacitation, motility of mammalian spermatozoon is changed from a state of "activation" to "hyperactivation." Recently, it has been suggested that some hormones present in the oviduct are involved in the regulation of this hyperactivation in vitro. Progesterone, melatonin, and serotonin enhance hyperactivation through specific membrane receptors, and 17β-estradiol suppresses this enhancement by progesterone and melatonin via a membrane estrogen receptor. Moreover, γ-aminobutyric acid suppresses progesterone-enhanced hyperactivation through the γ-aminobutyric acid receptor. These hormones dose-dependently affect hyperactivation. Although the complete signaling pathway is not clear, progesterone activates phospholipase C and protein kinases and enhances tyrosine phosphorylation. Moreover, tyrosine phosphorylation is suppressed by 17β-estradiol. This regulation of spermatozoal hyperactivation by steroids is also disrupted by diethylstilbestrol. The in vitro experiments reviewed here suggest that mammalian spermatozoa are able to respond to effects of oviductal hormones. We therefore assume that the enhancement of spermatozoal hyperactivation is also regulated by oviductal hormones in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.