Evidence map›Paper›PMID 26540250›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2016

Increased monocytes and bands following a red blood cell transfusion.

A M Ellefson, R G Locke, Y Zhao, A B Mackley, D A Paul

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Outcomes after implementing restrictive blood transfusion criteria in extremely premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

A M EllefsonSection of Neonatology, Department of Pediatrics, Christiana Care Health System, Newark, DE, USA.
R G LockeSection of Neonatology, Department of Pediatrics, Christiana Care Health System, Newark, DE, USA.
Y ZhaoBlood Bank, Christiana Care Health System, Newark, DE, USA.
A B MackleySection of Neonatology, Department of Pediatrics, Christiana Care Health System, Newark, DE, USA.
D A PaulSection of Neonatology, Department of Pediatrics, Christiana Care Health System, Newark, DE, USA.
Christiana Care Health System · USJefferson College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study is to analyze the white blood cell changes that occur after a transfusion of red blood cells in order to identify a subclinical inflammatory response in neonates. STUDY

designRetrospective analysis of infants who received a red blood cell transfusion in an intensive care nursery. White blood cell results within 24 h pre- to 48 h post-transfusion were collected and analyzed. Statistical analysis included ANOVA, T-test, Mann-Whitney U test, Pearson's correlation and multivariable linear regression.

resultMonocytes (P=0.02) and bands (P=0.035) were increased post-transfusion. There were no differences in monocytes (P=0.46) or bands (P=0.56) between groups who did or did not have blood cultures obtained. There was no difference in monocytes between groups who did or did not have sepsis (P=0.88).

conclusionWe identified an elevation in monocytes and bands in the 48 h following a transfusion in premature infants. Our findings support a possible pro-inflammatory response related to transfusion of red blood cells.

Indexed as

Erythrocyte TransfusionHumansInfantInfant, NewbornInfant, PrematureLeukocyte CountMonocytesRetrospective Studies

Identifiers

PMID26540250
OpenAlexW2127291143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.