Observational studyJournal of perinatology : official journal of the California Perinatal Association2016
Diminished growth and lower adiposity in hyperglycemic very low birth weight neonates at 4 months corrected age.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Long-Term Outcomes after Early Neonatal Hyperglycemia in VLBW Infants: A Systematic Review.Neonatology · 2021Pooled it
- Intranasal Insulin Attenuates the Long-Term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats.Developmental neuroscience · 2022Trial
- Glucose disturbances in very low birth weight infants nearing term age-results from the prospective LIGHT-study using continuous glucose monitoring.European journal of pediatrics · 2025Observational
- Standardizing Neonatal Body Composition Assessment Using Air Displacement Plethysmography: Insights from the Bavarian Experience.Children (Basel, Switzerland) · 2025Article
- Management of Neonatal Hyperglycaemia in Sweden-A Survey Study.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Neonatal dysglycemia: a review of dysglycemia in relation to brain health and neurodevelopmental outcomes.Pediatric research · 2024Review
- Insulin-like growth factor-1 and insulin-like growth factor binding protein-3 as early predictors of growth, body composition, and neurodevelopment in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- A Higher Amount of Nutritional Intake as a Possible Cause of Hyperglycemia in Extremely Premature Infants in Parenteral and Enteral Nutrition at the Tertiary Neonatal Intensive Care Unit.Children (Basel, Switzerland) · 2023Article
- Hyperglycemia and prematurity: a narrative review.Pediatric research · 2023Review
- Identification of clinical factors associated with timing and duration of spontaneous regression of retinopathy of prematurity not requiring treatment.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Cerebral Effects of Neonatal Dysglycemia.Clinics in perinatology · 2022Review
- Small for Gestational Age Preterm Neonates Exhibit Defective GH/IGF1 Signaling Pathway.Frontiers in pediatrics · 2021Article
- Hyperglycaemia in the Newborn Infant. Physiology Verses Pathology.Frontiers in pediatrics · 2021Review
- Optimizing nutrition of the preterm infant.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCharacterize the relationship between neonatal hyperglycemia and growth and body composition at 4 months corrected age (CA) in very low birth weight (VLBW) preterm infants. STUDY
designA prospective study of VLBW appropriate-for-gestation infants (N=53). All blood glucose measurements in the first 14 days and nutritional intake and illness markers until discharge were recorded. Standard anthropometrics and body composition via air displacement plethysmography were measured near term CA and 4 months CA. Relationships between hyperglycemia and anthropometrics and body composition were examined using multivariate linear regression.
resultsInfants with >5 days of hyperglycemia were lighter (5345 vs 6455 g, P⩽0.001), shorter (57.9 vs 60.9 cm, P⩽0.01), had smaller occipital-frontal head circumference (39.4 vs 42.0 cm, P⩽0.05) and were leaner (percent body fat 15.0 vs 23.8, P⩽0.01) at 4 months CA than those who did not have hyperglycemia, including after correcting for nutritional and illness factors.
conclusionsNeonatal hyperglycemia in VLBW infants is associated with decreased body size and lower adiposity at 4 months CA independent of nutritional deficit, insulin use and illness. Downregulation of the growth hormone axis may be responsible. These changes may influence long-term growth and cognitive development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.