ArticlePloS one2015
Risk Factors for Lobar and Non-Lobar Intracerebral Hemorrhage in Patients with Vascular Disease.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Global DNA methylation and MTHFR gene polymorphism status of ghanaians with early-onset intracerebral hemorrhage: implications for future interventions.Equity neuroscience · 2026Article
- Imaging and Clinical Prognostic Features in Lobar Versus Deep Intracerebral Hemorrhage in an Unselected Swedish Population.European journal of neurology · 2025Article
- Association of Antithrombotic Drug Use With Incident Intracerebral Hemorrhage Location.Neurology · 2024Article
- Molecular biomarkers for vascular cognitive impairment and dementia.Nature reviews. Neurology · 2023Review
- Association Between Statin Use and Intracerebral Hemorrhage Location: A Nested Case-Control Registry Study.Neurology · 2023Article
- Review
- Educational Case: Cranial hemorrhage and traumatic brain injury.Academic pathology · 2022Article
- Risk factors for intracerebral haemorrhage - Results from a prospective population-based study.European stroke journal · 2020Article
- 4D Flat Panel Conebeam CTA for In Vivo Imaging of the Microvasculature of the Human Cortex with a Novel Software Prototype.AJNR. American journal of neuroradiology · 2020Article
- Race/ethnicity influences outcomes in young adults with supratentorial intracerebral hemorrhage.Neurology · 2020Article
- Blood Pressure Variability and Outcome in Patients with Acute Nonlobar Intracerebral Hemorrhage following Intensive Antihypertensive Treatment.Chinese medical journal · 2018Article
- Cerebral Arterial Stenosis in Patients with Spontaneous Intracerebral Hemorrhage.Journal of Korean Neurosurgical Society · 2017Article
- Age-Specific Vascular Risk Factor Profiles According to Stroke Subtype.Journal of the American Heart Association · 2017Article
- The impact of cerebrovascular aging on vascular cognitive impairment and dementia.Ageing research reviews · 2017Review
- Recurrent Intracerebral Hemorrhage: Associations with Comorbidities and Medicine with Antithrombotic Effects.PloS one · 2016Article
- Design and Experimental Evaluation of a Non-Invasive Microwave Head Imaging System for Intracranial Haemorrhage Detection.PloS one · 2016Article
- Normotensive state during acute phase of hypertensive intracerebral hemorrhage.Journal of neurosciences in rural practiceArticle
- Spontaneous Intracerebral Hemorrhage among Hypertensive Patients in Saudi Arabia: Study from a Tertiary Center.Saudi journal of medicine & medical sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLobar and non-lobar non-traumatic intracerebral hemorrhage (ICH) are presumably caused by different types of small vessel diseases. The aim of this study was to assess risk factors for ICH according to location.
methodsIn two large prospective studies, SMART (n = 9088) and ESPRIT (n = 2625), including patients with manifest cardiovascular, cerebrovascular or peripheral artery disease or with vascular risk factors, we investigated potential risk factors for ICH during follow-up according to lobar or non-lobar location by Cox proportional hazards analyses.
resultsDuring 65,156 patient years of follow up 19 patients had lobar ICH (incidence rate 29, 95% CI 19-42 per 100,000 person-years) and 24 non-lobar ICH (incidence rate 37, 95% CI 26-51 per 100,000 person-years). Age significantly increased the risk of lobar ICH (HR per 10 years increase 1.90; 95% CI 1.17-3.10) in the multivariable analysis, but not of non-lobar hemorrhage. Anticoagulant medication (HR 3.49; 95% CI 1.20-10.2) and male sex (HR 3.79; 95% CI 1.13-12.8) increased the risk of non-lobar but not lobar ICH.
conclusionThis study shows an elevated risk of future ICH in patients with manifestations of, or risk factors for, cardiovascular, cerebrovascular or peripheral artery disease. Our data suggest that risk factors for ICH vary according to location, supporting the hypothesis of a differential pathophysiology of lobar and non-lobar ICH.
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