ArticlePLoS genetics2015
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
119 citing papers in PubMed, 245 citations in OpenAlex.
- Genome-wide association analysis reveals genetic architecture of fertility traits in Sahiwal heifers and cows.Tropical animal health and production · 2026Article
- Comparative Genomics Reveals the Ancestral Recombination Landscape of Placental Mammals.bioRxiv : the preprint server for biology · 2026Article
- Article
- An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data.Molecular ecology · 2025Review
- Recombination events restored the functional horned haplotypes in the offspring of polled parents.Genetics, selection, evolution : GSE · 2025Article
- Genome landscape and genetic architecture of recombination in domestic goats (Capra hircus).Genetics, selection, evolution : GSE · 2025Article
- Multivariate Single-Step GWAS Reveals Pleiotropic Genomic Regions and Candidate Genes Associated with Male Scrotal Circumference and Female Fertility Traits in Retinta Beef Cattle.Veterinary sciences · 2025Article
- The genetic diversity of Indonesian cattle has been shaped by multiple introductions and adaptive introgression.Nature communications · 2025Article
- Genetics of recombination rate variation within and between species.Journal of evolutionary biology · 2025Article
- Exploring Meiotic Recombination and Its Potential Benefits in South African Beef Cattle: A Review.Veterinary sciences · 2025Review
- Comparative Phylogenetics Reveal Clade-specific Drivers of Recombination Rate Evolution Across Vertebrates.Molecular biology and evolution · 2025Article
- Independent genetic basis of meiotic crossover positioning and interference in domestic pigs.Scientific reports · 2025Article
- Out of Africa: genetic characterization and diversity of Mashona cattle in the United States.Journal of animal science · 2025Article
- Genome-wide local ancestry and the functional consequences of admixture in African and European cattle populations.Heredity · 2025Article
- Multiple losses of aKRAB from PRDM9 coincide with a teleost-specific intron size distribution.BMC biology · 2024Article
- A high-density linkage map reveals broad- and fine-scale sex differences in recombination in the hihi (stitchbird; Notiomystis cincta).Heredity · 2024Article
- The Genetic Architecture of Recombination Rates is Polygenic and Differs Between the Sexes in Wild House Sparrows (Passer domesticus).Molecular biology and evolution · 2024Article
- Male-biased recombination at chromosome ends in a songbird revealed by precisely mapping crossover positions.G3 (Bethesda, Md.) · 2024Article
- Understanding the Genetic Basis of Variation in Meiotic Recombination: Past, Present, and Future.Molecular biology and evolution · 2024Review
59 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meiotic recombination is an essential biological process that generates genetic diversity and ensures proper segregation of chromosomes during meiosis. From a large USDA dairy cattle pedigree with over half a million genotyped animals, we extracted 186,927 three-generation families, identified over 8.5 million maternal and paternal recombination events, and constructed sex-specific recombination maps for 59,309 autosomal SNPs. The recombination map spans for 25.5 Morgans in males and 23.2 Morgans in females, for a total studied region of 2,516 Mb (986 kb/cM in males and 1,085 kb/cM in females). The male map is 10% longer than the female map and the sex difference is most pronounced in the subtelomeric regions. We identified 1,792 male and 1,885 female putative recombination hotspots, with 720 hotspots shared between sexes. These hotspots encompass 3% of the genome but account for 25% of the genome-wide recombination events in both sexes. During the past forty years, males showed a decreasing trend in recombination rate that coincided with the artificial selection for milk production. Sex-specific GWAS analyses identified PRDM9 and CPLX1 to have significant effects on genome-wide recombination rate in both sexes. Two novel loci, NEK9 and REC114, were associated with recombination rate in both sexes, whereas three loci, MSH4, SMC3 and CEP55, affected recombination rate in females only. Among the multiple PRDM9 paralogues on the bovine genome, our GWAS of recombination hotspot usage together with linkage analysis identified the PRDM9 paralogue on chromosome 1 to be associated in the U.S. Holstein data. Given the largest sample size ever reported for such studies, our results reveal new insights into the understanding of cattle and mammalian recombination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.