Evidence map›Paper›PMID 26540176›Full record

ReviewAging2015

Systemic Problems: A perspective on stem cell aging and rejuvenation.

Irina M Conboy, Michael J Conboy, Justin Rebo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. GDF11: An emerging therapeutic target for liver diseases and fibrosis.Journal of cellular and molecular medicine · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Irina M ConboyDepartment of Bioengineering, UC Berkeley; QB3, CA 94709, USA.
Michael J ConboyDepartment of Bioengineering, UC Berkeley; QB3, CA 94709, USA.
Justin ReboDepartment of Bioengineering, UC Berkeley; QB3, CA 94709, USA.

Funding

NIA NIH HHS R56 AG04816
6 · The paper itself

Abstract

This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are "beyond parabiosis" for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.

Indexed as

Cellular SenescenceAdult Stem CellsAgingAnimalsBone Morphogenetic ProteinsGrowth Differentiation FactorsHumansParabiosisRejuvenationBone Morphogenetic ProteinsGDF11 protein, humanGrowth Differentiation Factorsagingneurogenesisparabiosisrejuvenationstem cells

Identifiers

PMID26540176
PMCPMC4637204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.