ArticleNutrients2015
Thyroid-Stimulating Hormone (TSH) Concentration at Birth in Belgian Neonates and Cognitive Development at Preschool Age.
Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Association Between Newborn Thyroid-Stimulating-Hormone Concentration and Neurodevelopment and Growth: a Systematic Review.Biological trace element research · 2022Pooled it
- Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.Thyroid : official journal of the American Thyroid Association · 2021Guideline
- Mild Variations in Thyroid Hormone Serum Concentrations Show Associations with the ET 6-6-R Developmental Test: Results from a Population-Based Pediatric Cohort in Germany.Hormone research in paediatrics · 2026Article
- Perinatal and Childhood Risk Factors of Adverse Early Childhood Developmental Outcomes: A Systematic Review Using a Socioecological Model.Children (Basel, Switzerland) · 2025Review
- Newborn screening for primary congenital hypothyroidism: past, present and future.European thyroid journal · 2025Review
- Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population.Children (Basel, Switzerland) · 2025Article
- Predictive factors for the diagnosis of permanent congenital hypothyroidism and its temporal changes in Sergipe, Brazil - A real-life retrospective study.Archives of endocrinology and metabolism · 2023Article
- Clinical survey of current practice regarding treatment of children with borderline thyroid abnormalities.Journal of paediatrics and child health · 2023Article
- Variation in Thyroid-Stimulating Hormone and Cognitive Disorders in Unmedicated Middle-Aged Patients with Major Depressive Disorder: A Proton Magnetic Resonance Spectroscopy Study.Mediators of inflammation · 2022Article
- Association of elevated neonatal thyroid-stimulating hormone levels with school performance and stimulant prescription for attention deficit hyperactivity disorder in childhood.European journal of pediatrics · 2021Article
- Cord Blood Thyroid Hormones and Neurodevelopment in 2-Year-Old Boys and Girls.Frontiers in nutrition · 2021Article
- Small for gestational age is a risk factor for thyroid dysfunction in preterm newborns.BMC pediatrics · 2020Article
- Neonatal Thyroxine, Maternal Thyroid Function, and Cognition in Mid-childhood in a US Cohort.Maternal and child health journal · 2020Article
- Article
- Advanced Maternal Age, Mode of Delivery, and Thyroid Hormone Levels in Chinese Newborns.Frontiers in endocrinology · 2019Article
- The complex aetiology of cerebral palsy.Nature reviews. Neurology · 2018Review
- Newborn Screening in the US May Miss Mild Persistent Hypothyroidism.The Journal of pediatrics · 2018Article
- Are lower TSH cutoffs in neonatal screening for congenital hypothyroidism warranted?European journal of endocrinology · 2017Review
- Congenital hypothyroidism: insights into pathogenesis and treatment.International journal of pediatric endocrinology · 2017Review
- Neonatal thyroid-stimulating hormone concentration and psychomotor development at preschool age.Archives of disease in childhood · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main objective of the study was to investigate the effect of MID during late pregnancy, assessed by the thyroid-stimulating hormone (TSH) concentration at neonatal screening, on cognitive development of preschool children. A retrospective cohort study including 311 Belgian preschool children of 4-6 years old was conducted. Children were selected at random from the total list of neonates screened in 2008, 2009, and 2010 by the Brussels new-born screening center. Infants with congenital hypothyroidism, low birth weight, and/or prematurity were excluded from the selection. The selected children were stratified by gender and TSH-range (0.45-15 mIU/L). Cognitive abilities were assessed using Wechsler Preschool and Primary Scale of Intelligence-third edition. In addition, several socioeconomic, parental, and child confounding factors were assessed. Neonatal TSH concentration-a surrogate marker for MID-was not associated with Full Scale and Performance IQ scores in children. Lower Verbal IQ scores were found in children with neonatal TSH values comprised between 10-15 mIU/L compared to lower TSH levels in univariate analysis but these results did not hold when adjusting for confounding factors. Current levels of iodine deficiency among pregnant Belgian women may not be severe enough to affect the neurodevelopment of preschool children.
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