ArticleAmerican journal of respiratory and critical care medicine2016
Phenotype of Spirometric Impairment in an Aging Population.
Article in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- A Systematic Literature Review of the Humanistic Burden of COPD.International journal of chronic obstructive pulmonary diseasePooled it
- Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers.Chest · 2022Trial
- Trial
- Development and internal validation of the elderly COPD diagnostic score (ECDS): a multidimensional diagnostic tool for moderate-to-severe chronic obstructive pulmonary disease.Frontiers in medicine · 2026Article
- Incident arrhythmias in relation to ventilatory parameters and pulmonary disease: evidence from two prospective cohort studies.BMC medicine · 2025Article
- The association between muscle strength and z scores of pulmonary function.Scientific reports · 2025Article
- COPD Risk Phenotypes in Older Smokers: Evaluation in GLI- and GOLD-Defined Respiratory Impairment.Lung · 2024Article
- The Role of Pulmonary Function Testing in the Diagnosis and Management of COPD.Respiratory care · 2023Review
- Preserved ratio impaired spirometry with or without restrictive spirometric abnormality.Scientific reports · 2023Article
- Clinical Characteristics and Medical Utilization of Smokers with Preserved Ratio Impaired Spirometry.International journal of chronic obstructive pulmonary disease · 2023Article
- Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study.ERJ open research · 2021Article
- The ratio FEVClinical physiology and functional imaging · 2021Article
- A novel locus for exertional dyspnoea in childhood asthma.The European respiratory journal · 2021Article
- Clinical impact of forced vital capacity on exercise performance in patients with chronic obstructive pulmonary disease.Journal of thoracic disease · 2021Article
- Association between reproductive lifespan and lung function among postmenopausal women.Journal of thoracic disease · 2020Article
- GPs should not try to detect mild COPD.NPJ primary care respiratory medicine · 2020Article
- FEVRespiratory care · 2020Article
- Association of Symptoms of Obstructive Lung Disease and All-Cause Mortality in Older Adult Smokers.Journal of the American Geriatrics Society · 2019Article
- Restrictive Spirometric Pattern and Postoperative Pulmonary Complications Following Non-cardiothoracic Surgery.Scientific reports · 2019Article
- Physiologic Insights from the COPD Genetic Epidemiology Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019Review
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9 authors at 4 institutions in 1 country.
Funding
Abstract
rationaleThe Global Lung Initiative (GLI) provides age-appropriate criteria for establishing spirometric impairment, including mild, moderate, and severe chronic obstructive pulmonary disease (COPD) and restrictive pattern, but its association with respiratory-related phenotypes has not been evaluated.
objectivesTo evaluate respiratory-related phenotypes in GLI-defined spirometric impairment.
methodsIn COPDGene (N = 10,131 patients; age range, 45-81 yr; average smoking history, 44.3 pack-years), we evaluated spirometry, dyspnea (modified Medical Research Council grade, ≥2), poor respiratory health-related quality of life (St. George's Respiratory Questionnaire total score, ≥25), poor exercise performance (6-minute-walk distance, <391 m), bronchodilator reversibility (FEV1 change, >12% and ≥200 ml), and computed tomography-diagnosed emphysema and gas trapping (>5% and >15% of lung, respectively). MEASUREMENTS AND MAIN
resultsGLI established normal spirometry in 5,100 patients (50.3%), mild COPD in 669 (6.6%), moderate COPD in 865 (8.5%), severe COPD in 2,522 (24.9%), and restrictive pattern in 975 (9.6%). Relative to normal spirometry, graded associations with respiratory-related phenotypes were found for mild, moderate, and severe COPD, with respective adjusted odds ratios (95% confidence intervals) as follows: dyspnea-1.31 (1.10-1.56), 2.20 (1.81-2.68), and 10.73 (8.04-14.33); poor respiratory health-related quality of life-1.49 (1.28-1.75), 2.69 (2.08-3.47), and 14.61 (10.09-21.17); poor exercise performance-1.11 (0.94-1.31), 1.58 (1.33-1.88), and 4.58 (3.42-6.12); bronchodilator reversibility-2.76 (2.24-3.40), 5.18 (4.29-6.27), and 6.21 (5.06-7.62); emphysema-4.86 (3.16-7.47), 6.41 (4.09-10.05), and 17.79 (10.79-29.32); and gas trapping-3.92 (3.12-4.93), 5.20 (3.82-7.07), and 16.28 (9.71-27.30). Restrictive pattern was also associated with multiple respiratory-related phenotypes at a level similar to moderate COPD, but it was otherwise not associated with emphysema (0.89 [0.60-1.32]) or gas trapping (1.15 [0.92-1.42]).
conclusionsGLI-defined spirometric impairment establishes clinically meaningful respiratory disease, as validated by graded associations with respiratory-related phenotypes.
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