ArticleNeuron2015
Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Region-specific mechanosensation modulateseLife · 2026Article
- Interlocked transcription factor feedback loops maintain and restore adult touch sensation.Cell reports · 2026Article
- Anterior-posterior patterning in the chaetognath Spadella cephaloptera informs bilaterian nervous system and tail evolution.Communications biology · 2025Article
- Almost 40 years of studying homeobox genes in C. elegans.Development (Cambridge, England) · 2024Article
- Neurogenesis in Caenorhabditis elegans.Genetics · 2024Review
- A molecular atlas of adult C. elegans motor neurons reveals ancient diversity delineated by conserved transcription factor codes.Cell reports · 2024Article
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- Maintenance of neuronal identity in C. elegans and beyond: Lessons from transcription and chromatin factors.Seminars in cell & developmental biology · 2024Review
- Coordination of RAB-8 and RAB-11 during unconventional protein secretion.The Journal of cell biology · 2024Article
- Article
- Article
- Nervous system-wide analysis of Hox regulation of terminal neuronal fate specification in Caenorhabditis elegans.PLoS genetics · 2022Article
- Homeobox genes and the specification of neuronal identity.Nature reviews. Neuroscience · 2021Review
- Emerging Roles for Hox Proteins in the Last Steps of Neuronal Development in Worms, Flies, and Mice.Frontiers in neuroscience · 2021Review
- Intrinsic control of neuronal diversity and synaptic specificity in a proprioceptive circuit.eLife · 2020Article
- The Hox GeneJournal of developmental biology · 2020Article
- DamID identifies targets of CEH-60/PBX that are associated with neuron development and muscle structure in Caenorhabditis elegans.PloS one · 2020Article
- Article
- Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons ofDevelopment (Cambridge, England) · 2018Article
- Local microtubule organization promotes cargo transport inJournal of cell science · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although Hox genes specify the differentiation of neuronal subtypes along the anterior-posterior axis, their mode of action is not entirely understood. Using two subtypes of the touch receptor neurons (TRNs) in C. elegans, we found that a "posterior induction" mechanism underlies the Hox control of terminal neuronal differentiation. The anterior subtype maintains a default TRN state, whereas the posterior subtype undergoes further morphological and transcriptional specification induced by the posterior Hox proteins, mainly EGL-5/Abd-B. Misexpression of the posterior Hox proteins transformed the anterior TRN subtype toward a posterior identity both morphologically and genetically. The specification of the posterior subtype requires EGL-5-induced repression of TALE cofactors, which antagonize EGL-5 functions, and the activation of rfip-1, a component of recycling endosomes, which mediates Hox activities by promoting subtype-specific neurite outgrowth. Finally, EGL-5 is required for subtype-specific circuit formation by acting in both the sensory neuron and downstream interneuron to promote functional connectivity.
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