ArticleBioMed research international2015
Translational Medicine and Patient Safety in Europe: TRANSFoRm--Architecture for the Learning Health System in Europe.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 92 citations in OpenAlex.
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- Challenges to implementing electronic trial data collection in primary care: a qualitative study.BMC family practice · 2021Article
- Learning health systems in primary care: a systematic scoping review.BMC family practice · 2021Article
- A scoping review of clinical decision support tools that generate new knowledge to support decision making in real time.Journal of the American Medical Informatics Association : JAMIA · 2020Article
- Article
- A framework for value-creating learning health systems.Health research policy and systems · 2019Article
- Antibiotic prescribing for common infections in UK general practice: variability and drivers.The Journal of antimicrobial chemotherapy · 2019Observational
- India and the United Kingdom-What big data health research can do for a country.Learning health systems · 2019Article
- Preparing healthcare delivery organizations for managing computable knowledge.Learning health systems · 2019Article
- Exploring the role of competing demands and routines during the implementation of a self-management tool for type 2 diabetes: a theory-based qualitative interview study.BMC medical informatics and decision making · 2019Article
- Use of EHRs data for clinical research: Historical progress and current applications.Learning health systems · 2019Article
- Swiss Learning Health System: A national initiative to establish learning cycles for continuous health system improvement.Learning health systems · 2018Article
- The TRANSFoRm project: Experience and lessons learned regarding functional and interoperability requirements to support primary care.Learning health systems · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe Learning Health System (LHS) describes linking routine healthcare systems directly with both research translation and knowledge translation as an extension of the evidence-based medicine paradigm, taking advantage of the ubiquitous use of electronic health record (EHR) systems. TRANSFoRm is an EU FP7 project that seeks to develop an infrastructure for the LHS in European primary care.
methodsThe project is based on three clinical use cases, a genotype-phenotype study in diabetes, a randomised controlled trial with gastroesophageal reflux disease, and a diagnostic decision support system for chest pain, abdominal pain, and shortness of breath.
resultsFour models were developed (clinical research, clinical data, provenance, and diagnosis) that form the basis of the projects approach to interoperability. These models are maintained as ontologies with binding of terms to define precise data elements. CDISC ODM and SDM standards are extended using an archetype approach to enable a two-level model of individual data elements, representing both research content and clinical content. Separate configurations of the TRANSFoRm tools serve each use case.
conclusionsThe project has been successful in using ontologies and archetypes to develop a highly flexible solution to the problem of heterogeneity of data sources presented by the LHS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.