ArticleBioMed research international2015
Drift of Scroll Wave Filaments in an Anisotropic Model of the Left Ventricle of the Human Heart.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Monitoring and modulating cardiac bioelectricity: from Einthoven to end-user.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Review
- Reconstruction of excitation waves from mechanical deformation using physics-informed neural networks.Scientific reports · 2024Article
- The Ithildin library for efficient numerical solution of anisotropic reaction-diffusion problems in excitable media.PloS one · 2024Article
- Optical ventricular cardioversion by local optogenetic targeting and LED implantation in a cardiomyopathic rat model.Cardiovascular research · 2022Article
- Computationally efficient model of myocardial electromechanics for multiscale simulations.PloS one · 2021Article
- Anisotropic Cardiac Conduction.Arrhythmia & electrophysiology review · 2020Review
- Mechano-electric heterogeneity of the myocardium as a paradigm of its function.Progress in biophysics and molecular biology · 2016Review
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Authors and funding
4 authors.
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Abstract
Scroll waves are three-dimensional vortices which occur in excitable media. Their formation in the heart results in the onset of cardiac arrhythmias, and the dynamics of their filaments determine the arrhythmia type. Most studies of filament dynamics were performed in domains with simple geometries and generic description of the anisotropy of cardiac tissue. Recently, we developed an analytical model of fibre structure and anatomy of the left ventricle (LV) of the human heart. Here, we perform a systematic study of the dynamics of scroll wave filaments for the cases of positive and negative tension in this anatomical model. We study the various possible shapes of LV and different degree of anisotropy of cardiac tissue. We show that, for positive filament tension, the final position of scroll wave filament is mainly determined by the thickness of the myocardial wall but, however, anisotropy attracts the filament to the LV apex. For negative filament tension, the filament buckles, and for most cases, tends to the apex of the heart with no or slight dependency on the thickness of the LV. We discuss the mechanisms of the observed phenomena and their implications for cardiac arrhythmias.
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