ReviewFrontiers in bioengineering and biotechnology2015
Cold and Hot Extremozymes: Industrial Relevance and Current Trends.
Review in Frontiers in bioengineering and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
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Who cites it
122 citing papers in PubMed.
- Genome-Resolved Metagenomics Reveals Thermophilic Microbial Diversity and Putative Hydrolase-Encoding Genes in the El Tatio Geothermal Field.International journal of molecular sciences · 2026Article
- Partial purification and characterization of an extracellular cold-active protease from Flavobacterium azizsancarii, a novel Antarctic isolate.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Utilization of sugarcane bagasse waste by Aspergillus welwitchiae SVUAw9 for production, purification, and characterization of cold-active xylanase under solid-state fermentation conditions.Microbial cell factories · 2026Article
- Antioxidant, Anti-Inflammatory and Anticancer Peptides from Extreme Marine Environments.Antioxidants (Basel, Switzerland) · 2026Review
- Systematic screening of archaeal MazF homologs reveals Tth-MazF1, a versatile, sequence-specific ribonuclease from Thermococcus thioreducens.Nucleic acids research · 2026Article
- Enzymatic Properties and Multifunctional Applications of a Novel Extracellular Cold-Active Alkaline Protease from Stenotrophomonas maltophilia Strain TK-4.Applied biochemistry and biotechnology · 2026Article
- Combined computational, rational, and empirical design of boiling-resistant keratinase.Applied and environmental microbiology · 2026Article
- Mechanistic insights into a cold-adapted glucokinase with high thermal stability were revealed by site-directed spin labeling ESR.Biophysics and physicobiology · 2026Article
- Vulnerable microbial communities in Atacama-Altiplano wetlands: modern analogs of ancient ecosystems with implications for sustainability and conservation.FEMS microbes · 2026Review
- Molecular characterization, identification and enzyme-producing potential of thermophilic bacterial diversity isolated from the Kars sugar factory.BMC microbiology · 2025Article
- High hydrostatic pressure enhances chitinase activity and reveals metabolic regulation via transcriptomics in an abyssal fungus Purpureocillium lilacinum FDZ8Y1.Microbial cell factories · 2025Article
- Sustainable exploitation of high-protein feather waste for green production of cold-adapted and detergent-stable keratinase by Penicillium oxalicum AUMC 15084.World journal of microbiology & biotechnology · 2025Article
- Biochemical features and biotechnological potential of a proteolytic extract from a psychrophilic Antarctic bacterium.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Novel Antarctic Endo-Polygalacturonase for Pectin Extraction and Vegetal Tissue Maceration at Mild Temperatures.Applied biochemistry and biotechnology · 2025Article
- High-Spin States of Manganese(III) Enable Robust Cold-Adapted Activity of MnOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Extremophilic Microorganisms as a Source of Emerging Enzymes for the Food Industry: A Review.Food science & nutrition · 2025Review
- A novelFrontiers in microbiology · 2025Article
- Review
- Exploiting Archaeal/Thermostable Enzymes in Synthetic Chemistry: Back to the Future?ChemCatChem · 2024Article
- Cold-Active Lipase from the Ice CaveMolecules (Basel, Switzerland) · 2024Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of enzymes for industrial applications relies heavily on the use of microorganisms. The intrinsic properties of microbial enzymes, e.g., consistency, reproducibility, and high yields along with many others, have pushed their introduction into a wide range of products and industrial processes. Extremophilic microorganisms represent an underutilized and innovative source of novel enzymes. These microorganisms have developed unique mechanisms and molecular means to cope with extreme temperatures, acidic and basic pH, high salinity, high radiation, low water activity, and high metal concentrations among other environmental conditions. Extremophile-derived enzymes, or extremozymes, are able to catalyze chemical reactions under harsh conditions, like those found in industrial processes, which were previously not thought to be conducive for enzymatic activity. Due to their optimal activity and stability under extreme conditions, extremozymes offer new catalytic alternatives for current industrial applications. These extremozymes also represent the cornerstone for the development of environmentally friendly, efficient, and sustainable industrial technologies. Many advances in industrial biocatalysis have been achieved in recent years; however, the potential of biocatalysis through the use of extremozymes is far from being fully realized. In this article, the adaptations and significance of psychrophilic, thermophilic, and hyperthermophilic enzymes, and their applications in selected industrial markets will be reviewed. Also, the current challenges in the development and mass production of extremozymes as well as future prospects and trends for their biotechnological application will be discussed.
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