ArticleInternational journal of applied & basic medical research
Apelin protect against multiple organ injury following hemorrhagic shock and decrease the inflammatory response.
Article in International journal of applied & basic medical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Can Dietary n-3 Polyunsaturated Fatty Acids Affect Apelin and Resolvin in Testis and Sperm of Male Rabbits?Molecules (Basel, Switzerland) · 2023Article
- Review
- Effect of Omega-3 or Omega-6 Dietary Supplementation on Testicular Steroidogenesis, Adipokine Network, Cytokines, and Oxidative Stress in Adult Male Rats.Oxidative medicine and cellular longevity · 2021Article
- Fc-Elabela fusion protein attenuates lipopolysaccharide-induced kidney injury in mice.Bioscience reports · 2020Article
- Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats.Journal of neuroinflammation · 2019Article
- The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders.Annals of the New York Academy of Sciences · 2019Review
- Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction.Disease markers · 2018Review
- Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review.International journal of endocrinology · 2018Review
- Apelinergic System Structure and Function.Comprehensive Physiology · 2017Review
- Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth.Cancer letters · 2017Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHemorrhagic shock (HS) result in multiple organ injury and inflammatory response that lead to death. The exact mechanism is not clear. Apelin is an endogenous ligand of orphan G-protein coupled receptor APJ. Apelin has anti-inflammatory effects on the release of inflammatory mediators.
objectivesTo examine the protective effects of apelin against multiple organ injury and the possible involvement of inflammatory pathways. METHODOLOGY: Male Sprague-Dawley rats (300-350 g) were subjected to hemorrhage over 60 min to reach a mean arterial blood pressure of 40 mmHg. Then, rats were treated or not with 1 mL of 10 nm/L apelin-13 intraarterially resuscitation was performed in vivo by the reinfusion of the shed blood for 30 min to restore normotension. Blood samples were collected for measurement of tumor necrosis factor (TNF) using ELISA (R and D systems). Biopsies were obtained from organs for light microscopic examination.
resultsHS rats showed significant increase the levels of TNF. Apelin significantly lowered the production of TNF-α. Histological examination of hemorrhagic shocked untreated rats revealed structural damage. Less histological damage was observed in the organs of treated rats. Apelin-treatment decreased the number of inflammatory cells and mitochondrial swollen in cells.
conclusionTreatment with apelin before resuscitation protects against multiple organ injury in HS by attenuation the inflammatory response and might be a therapeutic target for HS.
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