ArticleJournal of Korean Neurosurgical Society2015
Efficacy and Safety of Fractionated Stereotactic Radiosurgery for Large Brain Metastases.
Article in Journal of Korean Neurosurgical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Single- and hypofractionated stereotactic radiosurgery for large (> 2 cm) brain metastases: a systematic review.Journal of neuro-oncology · 2021Pooled it
- Outcome of three-fraction gamma knife radiosurgery for brain metastases according to fractionation scheme: preliminary results.Journal of neuro-oncology · 2019Trial
- Fractionated Gamma Knife Radiosurgery as a Primary Treatment for Large Brain Metastases.Journal of Korean medical science · 2025Article
- Temporal evolution of MRI findings and survival outcomes in patients with brain metastases after stereotactic radiosurgery.BMC medical imaging · 2025Article
- Limitations of outcome prediction based on interfractional volume changes of large (≥ 10cmActa neurochirurgica · 2024Article
- Two-Day Fraction Gamma Knife Radiosurgery for Large Brain Metastasis.Journal of Korean Neurosurgical Society · 2024Article
- A 3-month survival model after Gamma Knife surgery in patients with brain metastasis from lung cancer with Karnofsky performance status ≤ 70.Scientific reports · 2023Article
- Fractionated versus staged gamma knife radiosurgery for mid-to-large brain metastases: a propensity score-matched analysis.Journal of neuro-oncology · 2023Article
- Article
- Stereotactic Radiation Therapy for Brain Metastases: Factors Affecting Outcomes and Radiation Necrosis.Cancers · 2023Article
- Five-Fraction Stereotactic Radiotherapy for Brain Metastases-A Retrospective Analysis.Current oncology (Toronto, Ont.) · 2023Article
- Retrospective study of hypofractionated stereotactic radiotherapy combined with whole brain radiotherapy for patients with brain metastases.Radiation oncology (London, England) · 2022Article
- Peri-radiosurgical administration of bevacizumab improves radiographic response to single and fractionated stereotactic radiosurgery for large brain metastasis.Journal of neuro-oncology · 2021Article
- Single- and Multifraction Stereotactic Radiosurgery Dose/Volume Tolerances of the Brain.International journal of radiation oncology, biology, physics · 2021Review
- Hypofractionated frameless gamma knife radiosurgery for large metastatic brain tumors.Clinical & experimental metastasis · 2021Article
- Positioning error analysis of the fraxion localization system in the intracranial stereotactic radiotherapy of tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Linac-based fractionated stereotactic radiotherapy with a micro-multileaf collimator for large brain metastasis unsuitable for surgical resection.Journal of radiation research · 2020Article
- A multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery for the treatment of brain metastasis.Radiation oncology (London, England) · 2020Article
- Current Treatment of Melanoma Brain Metastasis.Current treatment options in oncology · 2020Review
- Comparison of two-stage Gamma Knife radiosurgery outcomes for large brain metastases among primary cancers.Journal of neuro-oncology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the efficacy and safety of fractionated stereotactic radiosurgery for large brain metastases (BMs).
methodsBetween June 2011 and December 2013, a total of 38 large BMs >3.0 cm in 37 patients were treated with fractionated Cyberknife radiosurgery. These patients comprised 16 men (43.2%) and 21 women, with a median age of 60 years (range, 38-75 years). BMs originated from the lung (n=19, 51.4%), the gastrointestinal tract (n=10, 27.0%), the breast (n=5, 13.5%), and other tissues (n=3, 8.1%). The median tumor volume was 17.6 cc (range, 9.4-49.6 cc). For Cyberknife treatment, a median peripheral dose of 35 Gy (range, 30-41 Gy) was delivered in 3 to 5 fractions.
resultsWith a median follow-up of 10 months (range, 1-37 months), the crude local tumor control (LTC) rate was 86.8% and the estimated LTC rates at 12 and 24 months were 87.0% and 65.2%, respectively. The median overall survival (OS) and progression-free survival (PFS) rates were 16 and 11 months, respectively. The estimated OS and PFS rates at 6, 12, and 18 months were 81.1% and 65.5%, 56.8% and 44.9%, and 40.7% and 25.7%, respectively. Patient performance status and preoperative focal neurologic deficits improved in 20 of 35 (57.1%) and 12 of 17 patients (70.6%), respectively. Radiation necrosis with a toxicity grade of 2 or 3 occurred in 6 lesions (15.8%).
conclusionThese results suggest a promising role of fractionated stereotactic radiosurgery in treating large BMs in terms of both efficacy and safety.
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