ArticleFrontiers in microbiology2015
Membrane homeoviscous adaptation in the piezo-hyperthermophilic archaeon Thermococcus barophilus.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 84 citations in OpenAlex.
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- Bilayer-Forming Lipids Enhance Archaeal Monolayer Membrane Stability.International journal of molecular sciences · 2025Article
- High-pressure continuous culturing: life at the extreme.Applied and environmental microbiology · 2025Review
- Structure Diversity and Properties of Some Bola-like Natural Products.Marine drugs · 2024Review
- Microfluidics for studying the deep underground biosphere: from applications to fundamentals.FEMS microbiology ecology · 2024Review
- Unraveling the multiplicity of geranylgeranyl reductases in Archaea: potential roles in saturation of terpenoids.Extremophiles : life under extreme conditions · 2024Review
- Membrane homeostasis beyond fluidity: control of membrane compressibility.Trends in biochemical sciences · 2023Review
- Adaptations to high pressure of Nautilia sp. strain PV-1, a piezophilic Campylobacterium (aka Epsilonproteobacterium) isolated from a deep-sea hydrothermal vent.Environmental microbiology · 2022Article
- Vesicular and Planar Membranes of Archaea Lipids: Unusual Physical Properties and Biomedical Applications.International journal of molecular sciences · 2022Review
- Alkanes as Membrane Regulators of the Response of Early Membranes to Extreme Temperatures.Life (Basel, Switzerland) · 2022Article
- High-Pressure Microfluidics for Ultra-Fast Microbial Phenotyping.Frontiers in microbiology · 2022Article
- The Exploration of theFrontiers in microbiology · 2022Article
- Microbial membrane lipid adaptations to high hydrostatic pressure in the marine environment.Frontiers in molecular biosciences · 2022Review
- Article
- Non-Polar Lipids as Regulators of Membrane Properties in Archaeal Lipid Bilayer Mimics.International journal of molecular sciences · 2021Article
- Characterisation of a synthetic Archeal membrane reveals a possible new adaptation route to extreme conditions.Communications biology · 2021Article
- Alkanes increase the stability of early life membrane models under extreme pressure and temperature conditions.Communications chemistry · 2021Article
- The Piezo-Hyperthermophilic ArchaeonFrontiers in microbiology · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The archaeon Thermococcus barophilus, one of the most extreme members of hyperthermophilic piezophiles known thus far, is able to grow at temperatures up to 103°C and pressures up to 80 MPa. We analyzed the membrane lipids of T. barophilus by high performance liquid chromatography-mass spectrometry as a function of pressure and temperature. In contrast to previous reports, we show that under optimal growth conditions (40 MPa, 85°C) the membrane spanning tetraether lipid GDGT-0 (sometimes called caldarchaeol) is a major membrane lipid of T. barophilus together with archaeol. Increasing pressure and decreasing temperature lead to an increase of the proportion of archaeol. Reversely, a higher proportion of GDGT-0 is observed under low pressure and high temperature conditions. Noticeably, pressure and temperature fluctuations also impact the level of unsaturation of apolar lipids having an irregular polyisoprenoid carbon skeleton (unsaturated lycopane derivatives), suggesting a structural role for these neutral lipids in the membrane of T. barophilus. Whether these apolar lipids insert in the membrane or not remains to be addressed. However, our results raise questions about the structure of the membrane in this archaeon and other Archaea harboring a mixture of di- and tetraether lipids.
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