ArticleFrontiers in microbiology2015
The out-of-the-delta hypothesis: dense human populations in low-lying river deltas served as agents for the evolution of a deadly pathogen.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Genomes of Vibrio metoecus co-isolated with Vibrio cholerae extend our understanding of differences between these closely related species.Gut pathogens · 2022Article
- Dynamic Subspecies Population Structure of Vibrio cholerae in Dhaka, Bangladesh.Microbial ecology · 2022Article
- Simultaneous Quantification ofPathogens (Basel, Switzerland) · 2020Article
- A Vibrio cholerae Core Genome Multilocus Sequence Typing Scheme To Facilitate the Epidemiological Study of Cholera.Journal of bacteriology · 2020Article
- Responses of Free-LivingFrontiers in microbiology · 2020Article
- Environmental role of pathogenic traits inJournal of bacteriology · 2018Article
- Article
- Vibrio cholerae genomic diversity within and between patients.Microbial genomics · 2017Article
- Environmental investigation for the presence of Vibrio species following a case of severe gastroenteritis in a touristic island.Environmental science and pollution research international · 2017Article
- A Small Number of Phylogenetically Distinct Clonal Complexes Dominate a Coastal Vibrio cholerae Population.Applied and environmental microbiology · 2016Article
- Transmission of InfectiousFrontiers in microbiology · 2016Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholera is a diarrheal disease that has changed the history of mankind, devastating the world with seven pandemics from 1817 to the present day. Although there is little doubt in the causative agent of these pandemics being Vibrio cholerae of the O1 serogroup, where, when, and how this pathogen emerged is not well understood. V. cholerae is a ubiquitous coastal species that likely existed for tens of thousands of years. However, the evolution of a strain capable of causing a large-scale epidemic is likely more recent historically. Here, we propose that the unique human and physical geography of low-lying river deltas made it possible for an environmental bacterium to evolve into a deadly human pathogen. Such areas are often densely populated and salt intrusion in drinking water frequent. As V. cholerae is most abundant in brackish water, its favored environment, it is likely that coastal inhabitants would regularly ingest the bacterium and release it back in the environment. This creates a continuous selection pressure for V. cholerae to adapt to life in the human gut.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.