ArticleFrontiers in aging neuroscience2015
Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Trial
- Pulmonary Function Trajectories Preceding Death Among Older Adults: A Long-Term Community-Based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Association of impaired kidney function with dementia and brain pathologies: A community-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Poor pulmonary function is associated with mild cognitive impairment, its progression to dementia, and brain pathologies: A community-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Mixed Neuropathologies, Neural Motor Resilience and Target Discovery for Therapies of Late-Life Motor Impairment.Frontiers in human neuroscience · 2022Article
- Person-Specific Contributions of Brain Pathologies to Progressive Parkinsonism in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Genetic risk for Alzheimer's dementia predicts motor deficits through multi-omic systems in older adults.Translational psychiatry · 2019Article
- Spinal motor neurons and motor function in older adults.Journal of neurology · 2019Article
- Spinal Lewy body pathology in older adults without an antemortem diagnosis of Parkinson's disease.Brain pathology (Zurich, Switzerland) · 2018Article
- Article
- Religious Orders Study and Rush Memory and Aging Project.Journal of Alzheimer's disease : JAD · 2018Review
- Urinary Incontinence, Incident Parkinsonism, and Parkinson's Disease Pathology in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Incident parkinsonism in older adults without Parkinson disease.Neurology · 2016Article
- Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health.Alzheimer disease and associated disordersArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Damage to brain structures which constitute the distributed neural network that integrates respiratory muscle and pulmonary functions, can impair adequate ventilation and its volitional control. We tested the hypothesis that the level of brain pathology in older adults is associated with declining respiratory function measured during life. 1,409 older adults had annual testing with spirometry (SPI) and respiratory muscle strength (RMS) based on maximal inspiratory and maximal expiratory pressures (MEPs). Those who died underwent structured brain autopsy. On average, during 5 years of follow-up, SPI and RMS showed progressive decline which was moderately correlated (ρ = 0.57, p < 0.001). Among decedents (N = 447), indices of brain neuropathologies showed differential associations with declining SPI and RMS. Nigral neuronal loss was associated with the person-specific decline in SPI (Estimate, -0.016 unit/year, S.E. 0.006, p = 0.009) and reduction of the slope variance was equal to 4%. By contrast, Alzheimer's disease (AD) pathology (Estimate, -0.030 unit/year, S.E. 0.009, p < 0.001) and macroscopic infarcts (-0.033 unit/year, S.E., 0.011, p = 0.003) were associated with the person-specific decline in RMS and reduction of the slope variance was equal to 7%. These results suggest that brain pathology is associated with the rate of declining respiratory function in older adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.