ArticleFrontiers in behavioral neuroscience2015
Everyday executive functions in Down syndrome from early childhood to young adulthood: evidence for both unique and shared characteristics compared to youth with sex chromosome trisomy (XXX and XXY).
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 58 citations in OpenAlex.
- Everyday Executive Functioning Profiles in Adults with Down Syndrome.Journal of autism and developmental disorders · 2026Article
- Elevated autistic traits and social anxiety, and reduced empathy in adult women with triple X syndrome.Journal of neurodevelopmental disorders · 2025Article
- Brain structure in triple X syndrome: regional gray matter volume and cortical thickness in adult women with 47,XXX karyotype.Journal of neurodevelopmental disorders · 2025Article
- Acceptability of a Novel Parent-Mediated Executive Function Intervention for Young Children With Down Syndrome in Italy.Journal of applied research in intellectual disabilities : JARID · 2025Article
- Klinefelter syndrome and ADHD: a short systematic review.Frontiers in psychiatry · 2025Review
- Neurocognitive and psychosocial outcomes in survivors of childhood leukemia with Down syndrome.Cancer medicine · 2024Article
- Implications of Using the BRIEF-Preschool With School-Age Children With Down Syndrome.American journal on intellectual and developmental disabilities · 2024Article
- Considerations for developing syndrome-informed early interventions for children with neurogenetic conditions.International review of research in developmental disabilities · 2024Article
- Altered Gut Microbiota Composition Is Associated with Difficulty in Explicit Emotion Regulation in Young Children.Microorganisms · 2023Article
- Associations between executive functions, intelligence and adaptive behaviour in children and adolescents with mild intellectual disability.Journal of intellectual disabilities : JOID · 2023Article
- Longitudinal Predictors of Neurodevelopmental Outcomes in Children with Down Syndrome.Developmental neuropsychology · 2023Article
- Cognitive flexibility assessment in youth with Down syndrome: Reliability, practice effects, and validity.Research in developmental disabilities · 2023Article
- Confirmatory factor analysis of the BRIEF2 in a sample of youth with Down syndrome.Journal of intellectual disability research : JIDR · 2023Article
- A 12-week exercise programme has a positive effect on everyday executive function in young people with Down syndrome: a pilot non-randomised controlled trial.Journal of intellectual disability research : JIDR · 2022Article
- The developmental impact of sex chromosome trisomies on emerging executive functions in young children: Evidence from neurocognitive tests and daily life skills.Genes, brain, and behavior · 2022Article
- Variegation of autism related traits across seven neurogenetic disorders.Translational psychiatry · 2022Article
- Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome.Frontiers in neuroscience · 2022Review
- Executive function as measured by the Behavior Rating Inventory of Executive Function-2: children and adolescents with Williams syndrome.Journal of intellectual disability research : JIDR · 2022Article
- Updated profiles of everyday executive function in youth with Down syndrome using the BRIEF-2.Journal of intellectual disability research : JIDR · 2022Article
- Executive functions and adaptive behaviour in individuals with Down syndrome.Journal of intellectual disability research : JIDR · 2022Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Executive functions (EF) are thought to be impaired in Down syndrome (DS) and sex chromosome trisomy (Klinefelter and Trisomy X syndromes; +1X). However, the syndromic specificity and developmental trajectories associated with EF difficulties in these groups are poorly understood. The current investigation (a) compared everyday EF difficulties in youth with DS, +1X, and typical development (TD); and (b) examined relations between age and EF difficulties in these two groups and a TD control group cross-sectionally. Study 1 investigated the syndromic specificity of EF profiles on the Behavior Rating Inventory of Executive Function (BRIEF) in DS (n = 30), +1X (n = 30), and a TD group (n = 30), ages 5-18 years. Study 2 examined age effects on EF in the same cross-sectional sample of participants included in Study 1. Study 3 sought to replicate Study 2's findings for DS by examining age-EF relations in a large independent sample of youth with DS (n = 85) and TD (n = 43), ages 4-24 years. Study 1 found evidence for both unique and shared EF impairments for the DS and +1X groups. Most notably, youth with +1X had relatively uniform EF impairments on the BRIEF scales, while the DS group showed an uneven BRIEF profile with relative strengths and weaknesses. Studies 2 and 3 provided support for fairly similar age-EF relations in the DS and TD groups. In contrast, for the +1X group, findings were mixed; 6 BRIEF scales showed similar age-EF relations to the TD group and 2 showed greater EF difficulties at older ages for +1X. These findings will be discussed within the context of efforts to identify syndrome specific cognitive-behavioral profiles for youth with different genetic syndromes in order to inform basic science investigations into the etiology of EF difficulties in these groups and to develop treatment approaches that are tailored to the needs of these groups.
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