ArticleJournal of human reproductive sciences
Microdeletion of Y chromosome as a cause of recurrent pregnancy loss.
Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- The paternal role in pregnancy loss.Andrology · 2025Review
- Paternal Contributions to Recurrent Pregnancy Loss: Mechanisms, Biomarkers, and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2024Review
- Clinical Analysis of Y Chromosome Microdeletions and Chromosomal Aberrations in 1596 Male Infertility Patients of the Zhuang Ethnic Group in Guangxi.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Association of Y chromosome AZF region microdeletions with recurrent miscarriage in Iranian couples: A case-control study.Molecular genetics & genomic medicine · 2024Article
- Y chromosome AZFc microdeletion may have negative effect on embryo euploidy: a retrospective cohort study.BMC medical genomics · 2023Article
- Male Contributory Factors in Recurrent Pregnancy Loss.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Recurrent miscarriage and male factor infertility: diagnostic and therapeutic implications. A narrative review.Central European journal of urology · 2023Review
- Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management.Medical review (2021) · 2022Review
- Male factor testing in recurrent pregnancy loss cases: A narrative review.International journal of reproductive biomedicine · 2022Review
- High incidences of chromosomal aberrations and Y chromosome micro-deletions as prominent causes for recurrent pregnancy losses in highly ethnic and consanguineous population.Archives of gynecology and obstetrics · 2022Article
- Prevalence of Y chromosome microdeletion in north Indian infertile males with spermatogenesis defect.Journal of genetics · 2021Article
- The male contribution to recurrent pregnancy loss.Translational andrology and urology · 2018Review
- Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2018Review
- Partial and complete microdeletions of Y chromosome in infertile males from South of Iran.Molecular biology research communications · 2016Article
- A Novel Balanced Chromosomal Translocation in an Azoospermic Male: A Case Report.Journal of reproduction & infertilityArticle
- Cytogenetic Screening in Couples with Recurrent Pregnancy Loss: A Single-Center Study and Review of Literature.Journal of human reproductive sciencesArticle
- Erratum: Microdeletion of Y chromosome as a cause of recurrent pregnancy loss.Journal of human reproductive sciencesArticle
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextIn majority of couples experiencing recurrent pregnancy loss (RPL), etiology is still unknown. Two genetic factors have been suggested to underlie miscarriage in a subset of patients, namely skewed X chromosome inactivation in females and Y chromosome microdeletions in their partners. In males, microdeletions of the Y chromosome are known to cause spermatogenetic failure and male infertility.
aimsThe aim of the study was to find out the role of Y chromosome microdeletion in male partners of couples experiencing RPL. SETTINGS AND
designUniversity hospital and genetic laboratory. Prospective case-control study. SUBJECTS AND
methods59 couples with a history of RPL and 20 fertile controls (FC) with no miscarriage were included in the study. The study subjects were divided into male partners of RPL couples with abnormal semen parameters (AS) (n = 8), and couples with normal semen parameters (NS) (n = 51). Fertile controls with normal semen parameters were (FC) (n = 20). Y chromosome microdeletion was performed on 40 male partners of RPL and 20 FC. STATISTICAL ANALYSIS USED: Chi-square test. P <0.05 were considered statistically significant.
results13 of the 40 RPL cases showed deletion in three azoospermia factor loci on the long arm of Y chromosome. The P value was significant with Y chromosome microdeletion in RPL cases as compared to 20 FC where no Y chromosome microdeletion was present.
conclusionsY chromosome microdeletion may be an important hidden cause of recurrent pregnancy miscarriage and can be offered to couples with the undiagnosed cause of miscarriage.
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