ReviewMediators of inflammation2015
Treatment of Cancer Pain by Targeting Cytokines.
Review in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Anti-Cancer Effects of Lycopene in Animal Models of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2020Pooled it
- Energy Metabolism and Cancer Pain: A Pathway to Innovative Treatment Strategies.Current topics in medicinal chemistry · 2026Review
- The Missing Link: Integrating Interventional Pain Management in the Era of Multimodal Oncology.Pain and therapy · 2025Review
- Cellular senescence in the innervated niche modulates cancer-associated pain: an emerging therapeutic target?Frontiers in immunology · 2025Review
- Efficacy of aerobic and resistance exercises on cancer pain: A meta-analysis of randomised controlled trials.Heliyon · 2024Review
- Review
- Acupuncture in hematologic malignancies and hematopoietic cell transplantation.Blood reviews · 2022Review
- Genetic Mouse Models to Study Pancreatic Cancer-Induced Pain and Reduction in Well-Being.Cells · 2022Article
- The Beneficial Effects of Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain and Associated Mood Disorders Induced by Paclitaxel in Mice.Biomolecules · 2022Article
- Altered metabolic connectivity between the amygdala and default mode network is related to pain perception in patients with cancer.Scientific reports · 2022Article
- Mechanisms, Mediators, and Moderators of the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy.Cancers · 2022Review
- Cancer cachexia: Pathophysiology and association with cancer-related pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain.Mediators of inflammation · 2022Article
- Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain.Cancer research · 2021Article
- Article
- The predictive value of serum lipids for eye metastases in male nasopharyngeal carcinoma patients.Bioscience reports · 2020Article
- Applying Serum Cytokine Levels to Predict Pain Severity in Cancer Patients.Journal of pain research · 2020Article
- Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management.Scientific reports · 2019Article
- Schwann cells shape the neuro-immune environs and control cancer progression.Cancer immunology, immunotherapy : CII · 2019Review
- Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions.Human cell · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation is one of the most important causes of the majority of cancer symptoms, including pain, fatigue, cachexia, and anorexia. Cancer pain affects 17 million people worldwide and can be caused by different mediators which act in primary efferent neurons directly or indirectly. Cytokines can be aberrantly produced by cancer and immune system cells and are of particular relevance in pain. Currently, there are very few strategies to control the release of cytokines that seems to be related to cancer pain. Nevertheless, in some cases, targeted drugs are available and in use for other diseases. In this paper, we aim to review the importance of cytokines in cancer pain and targeted strategies that can have an impact on controlling this symptom.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.