ArticleIndustrial & engineering chemistry research2015
Design and Evaluation of a Robust PID Controller for a Fully Implantable Artificial Pancreas.
Article in Industrial & engineering chemistry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 88 citations in OpenAlex.
- Adaptive Content Tuning of Social Network Digital Health Interventions Using Control Systems Engineering for Precision Public Health: Cluster Randomized Controlled Trial.Journal of medical Internet research · 2023Trial
- Reinforcement Learning: A Paradigm Shift in Personalized Blood Glucose Management for Diabetes.Biomedicines · 2024Article
- Recent advances in the precision control strategy of artificial pancreas.Medical & biological engineering & computing · 2024Review
- The artificial pancreas: two alternative approaches to achieve a fully closed-loop system with optimal glucose control.Journal of endocrinological investigation · 2024Review
- Evaluating Deep Q-Learning Algorithms for Controlling Blood Glucose in In Silico Type 1 Diabetes.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Adaptive Personalized Prior-Knowledge-Informed Model Predictive Control for Type 1 Diabetes.Control engineering practice · 2023Article
- Hardware-in-Loop Comparison of Physiological Closed-Loop Controllers for the Autonomous Management of Hypotension.Bioengineering (Basel, Switzerland) · 2022Article
- New Clamp-PID Algorithm for Automated Glucose Clamps Improves Clamp Quality.Journal of diabetes science and technology · 2022Article
- Evaluation of blood glucose level control in type 1 diabetic patients using deep reinforcement learning.PloS one · 2022Article
- Embedded Model Predictive Control for a Wearable Artificial Pancreas.IEEE transactions on control systems technology : a publication of the IEEE Control Systems Society · 2020Article
- Plasma-Insulin-Cognizant Adaptive Model Predictive Control for Artificial Pancreas Systems.Journal of process control · 2019Article
- A New Animal Model of Insulin-Glucose Dynamics in the Intraperitoneal Space Enhances Closed-Loop Control Performance.Journal of process control · 2019Article
- Intraperitoneal insulin delivery provides superior glycaemic regulation to subcutaneous insulin delivery in model predictive control-based fully-automated artificial pancreas in patients with type 1 diabetes: a pilot study.Diabetes, obesity & metabolism · 2017Article
- Design of a dual-hormone model predictive control for artificial pancreas with exercise model.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Treatment of type 1 diabetes mellitus could be greatly improved by applying a closed-loop control strategy to insulin delivery, also known as an artificial pancreas (AP). In this work, we outline the design of a fully implantable AP using intraperitoneal (IP) insulin delivery and glucose sensing. The design process utilizes the rapid glucose sensing and insulin action offered by the IP space to tune a PID controller with insulin feedback to provide safe and effective insulin delivery. The controller was tuned to meet robust performance and stability specifications. An anti-reset windup strategy was introduced to prevent dangerous undershoot toward hypoglycemia after a large meal disturbance. The final controller design achieved 78% of time within the tight glycemic range of 80-140 mg/dL, with no time spent in hypoglycemia. The next step is to test this controller design in an animal model to evaluate the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.