ArticleProceedings. Biological sciences2015
Phage selection for bacterial cheats leads to population decline.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Forging the iron-net: Towards a quantitative understanding of microbial communities via siderophore-mediated interactions.Quantitative biology (Beijing, China) · 2025Article
- Ecological histories govern social exploitation by microorganisms.The ISME journal · 2025Article
- The potential of novel bacterial isolates from healthy ginseng for the control of ginseng root rot disease (Fusarium oxysporum).PloS one · 2022Article
- Advances in Phage Therapy: Targeting theViruses · 2021Review
- Evaluating kin and group selection as tools for quantitative analysis of microbial data.Proceedings. Biological sciences · 2021Article
- Hidden paths to endless forms most wonderful: parasite-blind diversification of host quality.Proceedings. Biological sciences · 2021Article
- More than Simple Parasites: the Sociobiology of Bacteriophages and Their Bacterial Hosts.mBio · 2020Review
- Bacterial siderophores in community and host interactions.Nature reviews. Microbiology · 2020Review
- Transposable temperate phages promote the evolution of divergent social strategies inProceedings. Biological sciences · 2019Article
- Adaptation to public goods cheats inProceedings. Biological sciences · 2017Article
- Bacterial competition and quorum-sensing signalling shape the eco-evolutionary outcomes of modelEvolutionary applications · 2017Article
- Antibiotic stress selects against cooperation in the pathogenic bacterium Pseudomonas aeruginosa.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While predators and parasites are known for their effects on bacterial population biology, their impact on the dynamics of bacterial social evolution remains largely unclear. Siderophores are iron-chelating molecules that are key to the survival of certain bacterial species in iron-limited environments, but their production can be subject to cheating by non-producing genotypes. In a selection experiment conducted over approximately 20 bacterial generations and involving 140 populations of the pathogenic bacterium Pseudomonas aeruginosa PAO1, we assessed the impact of a lytic phage on competition between siderophore producers and non-producers. We show that the presence of lytic phages favours the non-producing genotype in competition, regardless of whether iron use relies on siderophores. Interestingly, phage pressure resulted in higher siderophore production, which constitutes a cost to the producers and may explain why they were outcompeted by non-producers. By the end of the experiment, however, cheating load reduced the fitness of mixed populations relative to producer monocultures, and only monocultures of producers managed to grow in the presence of phage in situations where siderophores were necessary to access iron. These results suggest that public goods production may be modulated in the presence of natural enemies with consequences for the evolution of social strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.