Evidence map›Paper›PMID 26538526›Full record

ReviewJournal of leukocyte biology2016

Long noncoding RNAs in T lymphocytes.

Thomas M Aune, Phillip S Crooke, Charles F Spurlock

Abstract readReview
In one paragraph

Review in Journal of leukocyte biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Expression analysis of long non-coding RNAs and their target genes in multiple sclerosis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Article
  13. Review
  14. Review
  15. Article
  16. The emerging role of long non-coding RNA in spinal cord injury.Journal of cellular and molecular medicine · 2018
    Review
  17. Article
  18. Observational
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thomas M AuneDepartments of *Medicine and Mathematics, Vanderbilt University, Nashville, Tennessee, USA tom.aune@vanderbilt.edu.
Phillip S CrookeDepartments of *Medicine and Mathematics, Vanderbilt University, Nashville, Tennessee, USA.
Charles F SpurlockDepartments of *Medicine and Mathematics, Vanderbilt University, Nashville, Tennessee, USA.
Vanderbilt University · US

Funding

IFN GAMMA GENE REGULATION IN T CELLS AND NK CELLSR01AI044924 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AUNE, THOMAS M. · 2000 to 2019
$5.8M
Cell cycle checkpoint defects lead to chronic inflammation in RAR21AR063846 · NIAMS · VANDERBILT UNIVERSITY · PI AUNE, THOMAS M. · 2013 to 2014
$373k
NIAID NIH HHS R01 AI044924NIAMS NIH HHS R21 AR063846
6 · The paper itself

Abstract

Long noncoding RNAs are recently discovered regulatory RNA molecules that do not code for proteins but influence a vast array of biologic processes. In vertebrates, the number of long noncoding RNA genes is thought to greatly exceed the number of protein-coding genes. It is also thought that long noncoding RNAs drive the biologic complexity observed in vertebrates compared with that in invertebrates. Evidence of this complexity has been found in the T-lymphocyte compartment of the adaptive immune system. In the present review, we describe our current level of understanding of the expression of specific long or large intergenic or intervening long noncoding RNAs during T-lymphocyte development in the thymus and differentiation in the periphery and highlight the mechanisms of action that specific long noncoding RNAs employ to regulate T-lymphocyte function, both in vitro and in vivo.

Indexed as

AnimalsAutoimmune DiseasesCell DifferentiationCell LineageComputational BiologyGene Expression RegulationGenome-Wide Association StudyHumansImmunityOrgan SpecificityRNA, Long NoncodingT-LymphocytesT-Lymphocyte SubsetsRNA, Long Noncodingadaptive immunityepigeneticslncRNA

Identifiers

PMID26538526
PMCPMC6608032
OpenAlexW2189787879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.