ArticleScientific reports2015
Genetic evidence of a recent Tibetan ancestry to Sherpas in the Himalayan region.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Large-scale mitogenome analysis reveals complex maternal genetic connections between Sino-Tibetan- and Altaic-speaking populations.Human genetics · 2026Article
- Comparing integrative ventilatory and renal acid-base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unraveling the paternal genetic structure and forensic traits of the Hui population in Liaoning Province, China using Y-chromosome analysis.BMC genomics · 2023Article
- Article
- Whole mitochondrial genome analysis in highland Tibetans: further matrilineal genetic structure exploration.Frontiers in genetics · 2023Article
- Pulmonary vascular reactivity to supplemental oxygen in Sherpa and lowlanders during gradual ascent to high altitude.Experimental physiology · 2023Article
- Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia.PloS one · 2022Article
- Article
- Analysis of human mitochondrial genome co-occurrence networks of Asian population at varying altitudes.Scientific reports · 2021Article
- Population History and Altitude-Related Adaptation in the Sherpa.Frontiers in physiology · 2019Review
- Demographic History and Genetic Adaptation in the Himalayan Region Inferred from Genome-Wide SNP Genotypes of 49 Populations.Molecular biology and evolution · 2018Article
- Thrifty phenotype versus cold adaptation: trade-offs in upper limb proportions of Himalayan populations of Nepal.Royal Society open science · 2018Article
- Reconstructing the demographic history of the Himalayan and adjoining populations.Human genetics · 2018Article
- Ancient Human Migrations to and through Jammu Kashmir- India were not of Males Exclusively.Scientific reports · 2018Article
- The genomic landscape of Nepalese Tibeto-Burmans reveals new insights into the recent peopling of Southern Himalayas.Scientific reports · 2017Article
- Differentiated demographic histories and local adaptations between Sherpas and Tibetans.Genome biology · 2017Article
- Genetic structure in the Sherpa and neighboring Nepalese populations.BMC genomics · 2017Article
- Sherpas share genetic variations with Tibetans for high-altitude adaptation.Molecular genetics & genomic medicine · 2017Article
- Ancestral Origins and Genetic History of Tibetan Highlanders.American journal of human genetics · 2016Article
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17 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Sherpas living around the Himalayas are renowned as high-altitude mountain climbers but when and where the Sherpa people originated from remains contentious. In this study, we collected DNA samples from 582 Sherpas living in Nepal and Tibet Autonomous Region of China to study the genetic diversity of both their maternal (mitochondrial DNA) and paternal (Y chromosome) lineages. Analysis showed that Sherpas share most of their paternal and maternal lineages with indigenous Tibetans, representing a recently derived sub-lineage. The estimated ages of two Sherpa-specific mtDNA sub-haplogroups (C4a3b1 and A15c1) indicate a shallow genetic divergence between Sherpas and Tibetans less than 1,500 years ago. These findings reject the previous theory that Sherpa and Han Chinese served as dual ancestral populations of Tibetans, and conversely suggest that Tibetans are the ancestral populations of the Sherpas, whose adaptive traits for high altitude were recently inherited from their ancestors in Tibet.
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