ArticleJournal of cellular and molecular medicine2016
Influence of Klotho gene polymorphisms on vascular gene expression and its relationship to cardiovascular disease.
Article in Journal of cellular and molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Nitride oxide synthase 3 and klotho gene polymorphisms in the pathogenesis of chronic kidney disease and age-related cognitive impairment: a systematic review and meta-analysis.F1000Research · 2020Pooled it
- Assessment of Cardiovascular Risk and Examination of Blood Klotho Levels in Patients with Ankylosing Spondylitis.Journal of clinical medicine · 2025Article
- The association between dietary total antioxidant capacity and gene expression of Klotho in Iranians.Genes & nutrition · 2025Article
- The inflection point: α-Klotho levels and the risk of all-cause mortality.Frontiers in endocrinology · 2025Article
- Association ofJournal of diabetes and metabolic disorders · 2024Article
- Involvement of Single Nucleotide Variants in theDiabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Determination of the Relationship Between DNA Methylation Status ofBalkan journal of medical genetics : BJMG · 2023Article
- Klotho (rs1207568 and rs564481) gene variants and colorectal cancer risk.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Klotho and the Treatment of Human Malignancies.Cancers · 2020Review
- KLOTHO polymorphisms and age-related outcomes in community-dwelling older subjects: The São Paulo Ageing & Health (SPAH) Study.Scientific reports · 2020Article
- Klotho and vitamin D in multiple sclerosis: an Italian study.Archives of medical science : AMS · 2020Article
- FGF23 and Klotho Levels are Independently Associated with Diabetic Foot Syndrome in Type 2 Diabetes Mellitus.Journal of clinical medicine · 2019Article
- Update on Chronic Kidney Disease Mineral and Bone Disorder in Cardiovascular Disease.Seminars in nephrology · 2018Review
- Klotho G-395A gene polymorphism: impact on progression of end-stage renal disease and development of cardiovascular complications in children on dialysis.Pediatric nephrology (Berlin, Germany) · 2018Article
- A high-fat diet stimulates fibroblast growth factor 23 formation in mice through TNFα upregulation.Nutrition & diabetes · 2018Article
- Correlation betweenOncotarget · 2017Article
- From "Kidneys Govern Bones" to Chronic Kidney Disease, Diabetes Mellitus, and Metabolic Bone Disorder: A Crosstalk between Traditional Chinese Medicine and Modern Science.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- The effects of aerobic and anaerobic exercises on circulating soluble-Klotho and IGF-I in young and elderly adults and in CAD patients.Journal of circulating biomarkersReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klotho protein has been associated with beneficial effects that contribute to the maintenance of cardiovascular health. Diverse studies suggest that alterations in the levels of this molecule may be associated with pathophysiological abnormalities that result in increased cardiovascular risk. The primary aim of this proof-of-concept study was to analyse the existence of a potential link between Klotho gene polymorphisms and the expression level of this gene in the vascular wall, and additionally with the incidence of cardiovascular disease and cardiovascular risk factors. Our results indicate that the variant G-395A, located in the promoter region, influences Klotho gene vascular expression and is associated with the incidence of diabetes. Similarly, the exonic variant KL-VS was associated with the incidence of atherosclerotic vascular disease and coronary artery disease. Moreover, vascular expression levels of Klotho were related with the incidence of diabetes mellitus and coronary artery disease. These findings, which need to be confirmed in larger studies, suggest a potential role of Klotho in the pathogenesis of vascular damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.