Evidence map›Paper›PMID 26538263›Full record

ArticleCurrent treatment options in neurology2015

Evidence for the Importance of Vitamin D Status in Neurologic Conditions.

Anusha K Yeshokumar, Deanna Saylor, Michael D Kornberg, Ellen M Mowry

Abstract read
PubMed Publisher
In one paragraph

Article in Current treatment options in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Vitamin D in Neurological Diseases.International journal of molecular sciences · 2022
    Review
  4. Article
  5. Review
  6. Blood biomarkers with Parkinson's disease clusters and prognosis: The oxford discovery cohort.Movement disorders : official journal of the Movement Disorder Society · 2020
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anusha K YeshokumarDepartment of Neurology, Johns Hopkins University, Meyer 6-113, Baltimore, MD, 21287, USA. ayeshok1@jhmi.edu.
Deanna SaylorDepartment of Neurology, Johns Hopkins University, Meyer 6-113, Baltimore, MD, 21287, USA.
Michael D KornbergDepartment of Neurology, Johns Hopkins University, Meyer 6-113, Baltimore, MD, 21287, USA.
Ellen M MowryDepartment of Neurology, Johns Hopkins University, Meyer 6-113, Baltimore, MD, 21287, USA.
Johns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

opinion statementVitamin D status has been proposed as relevant to many neurological disorders. Data suggest that vitamin D may be important for the development of the nervous system, and it also plays a role in neuroimmunology and neuroprotection. Lower levels of circulating 25-hydroxyvitamin D have been linked with increased risk of multiple sclerosis (MS) and Alzheimer's disease (AD). While people with amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and stroke have lower vitamin D levels than those without the diseases, it is unclear if this is because hypovitaminosis D contributes to disease risk or is a consequence of immobility and other factors caused by the disease. Lower levels of vitamin D have been associated with worse prognosis in MS, PD, ALS, and stroke, while no longitudinal studies have been performed to evaluate such an association in AD. Small pilot trials have been performed to evaluate vitamin D supplementation for some of these diseases, but there have been no phase III studies to support vitamin D supplementation in these patient populations; further, ideal levels of 25-hydroxyvitamin D are not known. Thus, while some expert panels or individuals have suggested routine testing and supplementation for patients with these neurological conditions, it is our opinion that there are currently insufficient data to support high-dose vitamin D supplementation to specifically treat or prevent these conditions.

Indexed as

Alzheimer’s diseaseAmyotrophic lateral sclerosisCentral nervous systemMultiple sclerosisParkinson’s diseaseStrokeVitamin D

Identifiers

PMID26538263
OpenAlexW2214336679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.