Evidence map›Paper›PMID 26538244›Full record

ArticleBehavior genetics2016

Gene-Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood: Is APOE a Variability Gene?

Chandra A Reynolds, Margaret Gatz, Kaare Christensen, Lene Christiansen, Anna K Dahl Aslan, Jaakko Kaprio, Tellervo Korhonen, William S Kremen, Robert Krueger, Matt McGue and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavior genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Trial
  2. Article
  3. The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2026
    Article
  4. Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chandra A ReynoldsDepartment of Psychology, University of California Riverside, 900 University Ave., Riverside, CA, 92521, USA. chandra.reynolds@ucr.edu.
Margaret GatzDepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USA.
Kaare ChristensenEpidemiology, Biostatistics and Bio-demography, Institute of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
Lene ChristiansenEpidemiology, Biostatistics and Bio-demography, Institute of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
Anna K Dahl AslanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, 17177, Stockholm, Sweden.
Jaakko KaprioDepartment of Public Health & Institute for Molecular Medicine FIMM, University of Helsinki, 00014, Helsinki, Finland.
Tellervo KorhonenDepartment of Public Health, University of Helsinki, 00014, Helsinki, Finland.
William S KremenDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.
Robert KruegerDepartment of Psychology, University of Minnesota, Minneapolis, MN, 55455, USA.
Matt McGueEpidemiology, Biostatistics and Bio-demography, Institute of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
Jenae M NeiderhiserDepartment of Psychology, The Pennsylvania State University, University Park, PA, USA.
Nancy L PedersenDepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USA.
Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium

Funding

U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI YASHIN, ANATOLIY I · 1990 to 2008
$17.5M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
Gene-Environment Interplay of Social Contexts and Aging-Related OutcomesR01AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 2010 to 2014
$3.2M
GENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8M
GENES, ENVIRONMENT, AND MATERNAL ADJUSTMENTR01MH054610 · NIMH · GEORGE WASHINGTON UNIVERSITY · PI NEIDERHISER, JENAE M. · 1996 to 2006
$2.7M
The VETSA Longitudinal Twin Study of Cortisol and AgingR01AG022982 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2004 to 2007
$2.6M
Gene-Environment Interplay of Social Contexts and Aging-Related OutcomesR56AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, PEDERSEN, NANCY L · 2016 to 2016
$818k
NIA NIH HHS P01 AG008761NIA NIH HHS P01 AG020166NIA NIH HHS P01 AG08761NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG022982NIA NIH HHS R01 AG037985NIA NIH HHS R01 AG04563NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG 06886NIA NIH HHS R01 AG08861NIA NIH HHS R01 AG10175NIA NIH HHS R56 AG037985NIA NIH HHS U19 AG051426NIMH NIH HHS R01 MH054610NIMH NIH HHS R01 MH54610
6 · The paper itself

Abstract

Despite emerging interest in gene-environment interaction (GxE) effects, there is a dearth of studies evaluating its potential relevance apart from specific hypothesized environments and biometrical variance trends. Using a monozygotic within-pair approach, we evaluated evidence of G×E for body mass index (BMI), depressive symptoms, and cognition (verbal, spatial, attention, working memory, perceptual speed) in twin studies from four countries. We also evaluated whether APOE is a 'variability gene' across these measures and whether it partly represents the 'G' in G×E effects. In all three domains, G×E effects were pervasive across country and gender, with small-to-moderate effects. Age-cohort trends were generally stable for BMI and depressive symptoms; however, they were variable-with both increasing and decreasing age-cohort trends-for different cognitive measures. Results also suggested that APOE may represent a 'variability gene' for depressive symptoms and spatial reasoning, but not for BMI or other cognitive measures. Hence, additional genes are salient beyond APOE.

Indexed as

AdultAgedAged, 80 and overAgingApolipoproteins EBody Mass IndexCognitionCognition DisordersDepressionEnvironmentFemaleGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleApolipoproteins EAPOEBMICognitive performanceDepressionGene–environment interactionTwinsVariability gene

Identifiers

PMID26538244
PMCPMC4858319

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.