ArticleMolecular biology of the cell2016
Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry.
Article in Molecular biology of the cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Epigenome-wide association analysis of prenatal organophosphate ester flame retardant exposure in maternal blood implicates maternal immune and neuronal epigenetic alterations.Environment international · 2026Article
- Identification of novel biallelic mutations in CFAP53 associated with fetal situs inversus totalis and literature review.Journal of applied genetics · 2026Review
- Association of serum coiled-coil domain containing protein 11 levels with coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- An Opto-Bio-Hydrodynamic Platform for Instructing Cardiac Left-Right Asymmetry Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation.Cytoskeleton (Hoboken, N.J.) · 2025Article
- Review
- Uncovering structural themes across cilia microtubule inner proteins with implications for human cilia function.Nature communications · 2024Article
- Article
- Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion.Development (Cambridge, England) · 2023Article
- GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program.Cell death & disease · 2023Article
- Review
- Bidirectional multiciliated cell extrusion is controlled by Notch driven basal extrusion and Piezo 1 driven apical extrusion.bioRxiv : the preprint server for biology · 2023Article
- SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming.Cell · 2023Article
- The centriolar satellite protein Cfap53 facilitates formation of the zygotic microtubule organizing center in the zebrafish embryo.Development (Cambridge, England) · 2022Article
- Homozygous mutation inFrontiers in genetics · 2022Article
- Article
- Essential Role of CFAP53 in Sperm Flagellum Biogenesis.Frontiers in cell and developmental biology · 2021Article
- CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.PLoS genetics · 2020Article
- Motile ciliopathies.Nature reviews. Disease primers · 2020Review
- Spatial and proteomic profiling reveals centrosome-independent features of centriolar satellites.The EMBO journal · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The establishment of left-right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and cellular functions of the protein remain unknown. Here we demonstrate that Ccdc11 is a novel component of centriolar satellites-cytoplasmic granules that serve as recruitment sites for proteins destined for the centrosome and cilium. Ccdc11 interacts with core components of satellites, and its loss disrupts the subcellular organization of satellite proteins and perturbs primary cilium assembly. Ccdc11 colocalizes with satellite proteins in human multiciliated tracheal epithelia, and its loss inhibits motile ciliogenesis. Similarly, depletion of CCDC11 in Xenopus embryos causes defective assembly and motility of cilia in multiciliated epidermal cells. To determine the role of CCDC11 during vertebrate development, we generated mutant alleles in zebrafish. Loss of CCDC11 leads to defective ciliogenesis in the pronephros and within the Kupffer's vesicle and results in aberrant L-R axis determination. Our results highlight a critical role for Ccdc11 in the assembly and function of motile cilia and implicate centriolar satellite-associated proteins as a new class of proteins in the pathology of L-R patterning and congenital heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.