ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016
Pediatric glioblastoma: a single institution experience.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Extent of Tumor Resection and Survival in Pediatric Patients With High-Grade Gliomas: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Personalized survival prediction in pediatric glioblastoma using a machine learning-powered web tool.Translational cancer research · 2026Article
- Long-Term Outcomes of Radiation Therapy for Pediatric Brain Tumors: A Single-Center Study.Cureus · 2025Article
- Novel insights on genetics and epigenetics as clinical targets for paediatric astrocytoma.Clinical and translational medicine · 2024Review
- Article
- Prognostic factors for pediatric, adolescent, and young adult patients with non-DIPG grade 4 gliomas: a contemporary pooled institutional experience.Journal of neuro-oncology · 2023Article
- Pediatric glioblastoma: mechanisms of immune evasion and potential therapeutic opportunities.Cancer immunology, immunotherapy : CII · 2022Review
- Novel Pharmacological Treatment Options in Pediatric Glioblastoma-A Systematic Review.Cancers · 2022Review
- The role of sex genotype in paediatric CNS tumour incidence and survival.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Primary cerebellar glioblastomas in children: clinical presentation and management.Neurosurgical review · 2021Article
- Clinical behaviour and outcome in pediatric glioblastoma: current scenario.Radiation oncology journal · 2021Article
- Article
- AB Blood Group Confers Higher Risk for Primary Brain Tumors in Pediatrics.Risk management and healthcare policy · 2021Article
- Advanced Magnetic Resonance Imaging in Pediatric Glioblastomas.Frontiers in neurology · 2021Review
- H3K27M, IDH1, and ATRX expression in pediatric GBM and their clinical and prognostic significance.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Successful treatment of aBMJ case reports · 2019Article
- Stereotactic Placement of Intratumoral Catheters for Continuous Infusion Delivery of Herpes Simplex Virus -1 G207 in Pediatric Malignant Supratentorial Brain Tumors.World neurosurgery · 2019Article
- Evaluating extent of resection in pediatric glioblastoma: a multiple propensity score-adjusted population-based analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Childhood Pineal Glioblastoma: Case Report.Journal of pediatric neurosciencesArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to evaluate characteristics of childhood glioblastoma multiforme, effectiveness of treatment modalities, and detect factors related to outcome.
methodsA detailed analysis was performed on a series of 15 patients treated between 2000 and 2013, based on their clinical, radiologic, pathologic, treatment, and follow-up data.
resultsMedian survival time of children with glioblastoma was 13.5 months. One- and 2-year overall survival probabilities were 66.7 and 20 %, respectively. There were no significant differences in survival based on patients' gender, age, disease presentation with or without epileptic seizures, signs/symptoms of increased intracranial pressure, or tumor location. The presence of neurological deficit initially, as well as prior to radiotherapy, which was quantified by neurologic function score (NFS), had an impact on overall survival. Children with NFS 0 lived longer compared to others (p = 0.001). Survival of children that underwent gross total resection was longer than that of children that underwent subtotal resection (p = 0.030). Mean survival time of children with gross total resection was 73.5 months, compared to 13 months in children with subtotal resection. There was no significant correlation between outcome and type of radiotherapy. In four patients with gigantocellular glioblastoma, we found no evidence of a better prognosis. Two long-term survivors were recorded. Both of them underwent gross total resection and were assigned a NFS 0.
conclusionsGross total resection is essential for longer overall survival among pediatric patients with glioblastoma and offers a possibility for long-term survival. Severity of neurologic symptoms quantified by NFS can be considered as a potential predictor of outcome.
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Registered trials
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