Evidence map›Paper›PMID 26537907›Full record

Trial reportSurgical endoscopy2016

COLOR III: a multicentre randomised clinical trial comparing transanal TME versus laparoscopic TME for mid and low rectal cancer.

Charlotte L Deijen, Simone Velthuis, Alice Tsai, Stella Mavroveli, Elly S M de Lange-de Klerk, Colin Sietses, Jurriaan B Tuynman, Antonio M Lacy, George B Hanna, H Jaap Bonjer

4 registry-linked trialsOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 176 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 20 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03242187 phase2 / phase3unknown statusnot on this mapstarted 2017, after this paper: background citation

(MansTaTME) Trans-anal Versus Laparoscopic Total Mesorectal Excision for Mid and Low Rectal Cancer

TypeinterventionalSponsorMansoura UniversityRan2017 to 2019Enrolled30ConditionsRectal CancerArmsTrans-anal total mesorectal excision(TaTME), Lap. TME
NCT03349788 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Randomized Controlled Trial: Clinical Value of Preserving Left Colic Artery in Laparoscopic Radical Rectectomy

TypeinterventionalSponsorShanghai Minimally Invasive Surgery CenterRan2018 to 2022Enrolled354ConditionsOverall Survival, Postoperative ComplicationsArmsLCA-nP, LCA-P
NCT03413904 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Transanal Versus Laparoscopic Total Mesorectal Excision For Mid And Low Rectal Cancer. A Multicentre Randomised Clinical Trial on Anastomotic Leak

TypeinterventionalSponsorIRCCS San RaffaeleRan2018 to 2023Enrolled184ConditionsRectal CancerArmstransanal TME, laparoscopic TME
NCT03413930 nawithdrawnnot on this mapstarted 2019, after this paper: background citation

Single-center Prospective Randomized Controlled Study of the Transanal Total Mesorectal Excision Versus Laparoscopic Total Mesorectal Excision in Rectal Cancer

TypeinterventionalSponsorRuijin HospitalRan2019 to 2026Enrolled0ConditionsRectal CancerArmsTransanal total mesorectal excision, Laparoscopic total mesorectal excision
3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 20 syntheses or guidelines pooled it, 379 citations in OpenAlex.

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116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Charlotte L DeijenDepartment of Surgery, VU University Medical Centre, Postbus 7057, 1007 MB, Amsterdam, The Netherlands. c.deijen@vumc.nl.
Simone VelthuisDepartment of Surgery, Gelderse Vallei Hospital Ede, Ede, The Netherlands.
Alice TsaiDepartment of Surgery and Cancer, Imperial College London, London, UK.
Stella MavroveliDepartment of Surgery and Cancer, Imperial College London, London, UK.
Elly S M de Lange-de KlerkDepartment of Surgery, VU University Medical Centre, Postbus 7057, 1007 MB, Amsterdam, The Netherlands.
Colin SietsesDepartment of Surgery, Gelderse Vallei Hospital Ede, Ede, The Netherlands.
Jurriaan B TuynmanDepartment of Surgery, VU University Medical Centre, Postbus 7057, 1007 MB, Amsterdam, The Netherlands.
Antonio M LacyDepartment of Surgery, Hospital Clinic de Barcelona, Barcelona, Spain.
George B HannaDepartment of Surgery and Cancer, Imperial College London, London, UK.
H Jaap BonjerDepartment of Surgery, VU University Medical Centre, Postbus 7057, 1007 MB, Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NLImperial College London · GBZiekenhuis Gelderse Vallei · NLHospital Clínic de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTotal mesorectal excision (TME) is an essential component of surgical management of rectal cancer. Both open and laparoscopic TME have been proven to be oncologically safe. However, it remains a challenge to achieve complete TME with clear circumferential resections margin (CRM) with the conventional transabdominal approach, particularly in mid and low rectal tumours. Transanal TME (TaTME) was developed to improve oncological and functional outcomes of patients with mid and low rectal cancer.

methodsAn international, multicentre, superiority, randomised trial was designed to compare TaTME and conventional laparoscopic TME as the surgical treatment of mid and low rectal carcinomas. The primary endpoint is involved CRM. Secondary endpoints include completeness of mesorectum, residual mesorectum, morbidity and mortality, local recurrence, disease-free and overall survival, percentage of sphincter-saving procedures, functional outcome and quality of life. A Quality Assurance Protocol including centralised MRI review, histopathology re-evaluation, standardisation of surgical techniques, and monitoring and assessment of surgical quality will be conducted. DISCUSSION: The difference in involvement of CRM between the two treatment strategies is thought to be in favour of the TaTME. TaTME is therefore expected to be superior to laparoscopic TME in terms of oncological outcomes in case of mid and low rectal carcinomas.

Indexed as

Anal CanalCarcinomaDigestive System Surgical ProceduresDisease-Free SurvivalHumansLaparoscopyMargins of ExcisionMesenteryNeoplasm Recurrence, LocalOrgan Sparing TreatmentsQuality of LifeRectal NeoplasmsRectumSurvival RateTransanal Endoscopic SurgeryLaparoscopicRectal cancerSurgical qualityTaTMETMETotal mesorectal excisionTransanal

Identifiers

PMID26537907
PMCPMC4956704
OpenAlexW2146460633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.