ArticleScientific reports2015
Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 57 citations in OpenAlex.
- Review
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- Associations of obesity defined comprehensively by body mass index and body fat percentage with osteopenia.Clinics (Sao Paulo, Brazil) · 2025Article
- AeLife · 2024Article
- Generation of LEPR Knockout Rabbits with CRISPR/CAS9 System.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2024Article
- The AGEs/RAGE Signaling Pathway Regulates NLRP3-Mediated Neuronal Pyroptosis After MCAO Injury inJournal of inflammation research · 2024Article
- Association between Adiposity and Bone Mineral Density in Adults: Insights from a National Survey Analysis.Nutrients · 2023Article
- The roles of sclerostin and irisin on bone and muscle of orchiectomized rats.BMC musculoskeletal disorders · 2022Article
- CRISPR-Cas systems: role in cellular processes beyond adaptive immunity.Folia microbiologica · 2022Review
- Huangshan Maofeng Green Tea Extracts Prevent Obesity-Associated Metabolic Disorders by Maintaining Homeostasis of Gut Microbiota and Hepatic Lipid Classes in Leptin Receptor Knockout Rats.Foods (Basel, Switzerland) · 2022Article
- Current landscape of gene-editing technology in biomedicine: Applications, advantages, challenges, and perspectives.MedComm · 2022Review
- Obesity, Bone Loss, and Periodontitis: The Interlink.Biomolecules · 2022Review
- Large Yellow Tea Extract Ameliorates Metabolic Syndrome by Suppressing Lipogenesis through SIRT6/SREBP1 Pathway and Modulating Microbiota in Leptin Receptor Knockout Rats.Foods (Basel, Switzerland) · 2022Article
- Recent Advances in the Production of Genome-Edited Rats.International journal of molecular sciences · 2022Review
- IL-6 and Leptin Are Potential Biomarkers for Osteoporotic Fracture Risk Assessment and Prediction of Postmenopausal Women with Low Bone Mass: A Follow-Up Study Using a Regional Sample Cohort.Oxidative medicine and cellular longevity · 2022Article
- Obesity and Bone: A Complex Relationship.International journal of molecular sciences · 2021Review
- Gene expression atlas of energy balance brain regions.JCI insight · 2021Article
- Genome engineering and disease modelingWorld journal of stem cells · 2021Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptin receptor, which is encoded by the diabetes (db) gene and is highly expressed in the choroid plexus, regulatesenergy homeostasis, the balance between food intake and energy expenditure, fertility and bone mass. Here, using CRISPR/Cas9 technology, we created the leptin receptor knockout rat. Homozygous leptin receptor null rats are characterized by obesity, hyperphagia, hyperglycemia, glucose intolerance, hyperinsulinemia and dyslipidemia. Due to long-term poor glycemic control, the leptin receptor knockout rats also develop some diabetic complications such as pancreatic, hepatic and renal lesions. In addition, the leptin receptor knockout rats show a significant decrease in bone volume and bone mineral density of the femur compared with their wild-type littermates. Our model has rescued some deficiency of the existing rodent models, such as the transient hyperglycemia of db/db mice in the C57BL/6J genetic background and the delayed onset of glucose intolerance in the Zucker rats, and it is proven to be a useful animal model for biomedical and pharmacological research on obesity and diabetes.
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