Evidence map›Paper›PMID 26537729›Full record

ArticleMolecular diversity2016

Ethyl 3-(2,4-dioxocyclohexyl)propanoate as a novel precursor for N-substituted 4,4a,5,6-tetrahydroquinoline-2,7(1H,3H)-diones and their corresponding 3,4-dihydro-7-hydroxyquinolin-2(1H)-ones and 7-hydroxyquinolin-2(1H)-ones synthesis.

Vandna Thakur, Dharminder Sharma, Pralay Das

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vandna ThakurNatural Product Chemistry and Process Development, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P., 176061, India.
Dharminder SharmaNatural Product Chemistry and Process Development, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P., 176061, India.
Pralay DasNatural Product Chemistry and Process Development, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P., 176061, India. pdas@ihbt.res.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ethyl 3-(2,4-dioxocyclohexyl)propanoate has been explored as a precursor for the synthesis of N-substituted 4,4a,5,6-tetrahydroquinoline-2,7(1H,3H)-diones following conventional protecvtion, selective amidation, and deprotective-cyclization approaches. Moreover, a facile process for the selective dehydrogenative aromatization of these diones was developed to afford the corresponding N-substituted 3,4-dihydro-7-hydroxyquinolin-2(1H)-ones and N-substituted 7-hydroxyquinolin-2(1H)-ones under mild conditions.

Indexed as

HydroxyquinolinesMicrowavesMolecular StructurePropionatesHydroxyquinolinesPropionates7-Hydroxy-quinlin-2(1H)-oneCyclohexane-1, 3-dioneDehydrogenative aromatizationHeterocyclesMicrowave irradiationTetrahydroquinoline-2,7-dione

Identifiers

PMID26537729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.