Evidence map›Paper›PMID 26537708›Full record

SynthesisEuropean journal of epidemiology2015

Risk for childhood leukemia associated with maternal and paternal age.

Theodoros N Sergentanis, Thomas P Thomopoulos, Spyros P Gialamas, Maria A Karalexi, Stylianos-Iason Biniaris-Georgallis, Evangelia Kontogeorgi, Paraskevi Papathoma, Gerasimos Tsilimidos, Alkistis Skalkidou, Anastasia N Iliadou and 1 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Exposure to Acetaminophen (Paracetamol) during Pregnancy and Childhood Cancer: A Population-Based Cohort Study in Taiwan.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
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  14. Is There Etiologic Heterogeneity between Subtypes of Childhood Acute Lymphoblastic Leukemia? A Review of Variation in Risk by Subtype.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019
    Review
  15. Article
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  18. Infertility in the Aging Male.Current urology reports · 2018
    Review
  19. Parental Age and Risk of Infant Leukaemia: A Pooled Analysis.Paediatric and perinatal epidemiology · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Theodoros N SergentanisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, 75 M. Asias Str. Goudi, 115 27, Athens, Greece.
Thomas P ThomopoulosDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, 75 M. Asias Str. Goudi, 115 27, Athens, Greece.
Spyros P GialamasDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, 75 M. Asias Str. Goudi, 115 27, Athens, Greece.
Maria A KaralexiDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, 75 M. Asias Str. Goudi, 115 27, Athens, Greece.
Stylianos-Iason Biniaris-GeorgallisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, 75 M. Asias Str. Goudi, 115 27, Athens, Greece.
Evangelia KontogeorgiDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, 75 M. Asias Str. Goudi, 115 27, Athens, Greece.
Paraskevi PapathomaDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, 75 M. Asias Str. Goudi, 115 27, Athens, Greece.
Gerasimos TsilimidosDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, 75 M. Asias Str. Goudi, 115 27, Athens, Greece.
Alkistis SkalkidouDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Anastasia N IliadouDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Eleni T PetridouDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, 75 M. Asias Str. Goudi, 115 27, Athens, Greece. epetrid@med.uoa.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of reproductive factors, such as parental age, in the pathogenesis of childhood leukemias is being intensively examined; the results of individual studies are controversial. This meta-analysis aims to quantitatively synthesize the published data on the association between parental age and risk of two major distinct childhood leukemia types in the offspring. Eligible studies were identified and pooled relative risk (RR) estimates were calculated using random-effects models, separately for childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Subgroup analyses were performed by study design, geographical region, adjustment factors; sensitivity analyses and meta-regression analyses were also undertaken. 77 studies (69 case-control and eight cohort) were deemed eligible. Older maternal and paternal age were associated with increased risk for childhood ALL (pooled RR = 1.05, 95 % CI 1.01-1.10; pooled RR = 1.04, 95 % CI 1.00-1.08, per 5 year increments, respectively). The association between maternal age and risk of childhood AML showed a U-shaped pattern, with symmetrically associated increased risk in the oldest (pooled RR = 1.23, 95 % CI 1.06-1.43) and the youngest (pooled RR = 1.23, 95 % CI 1.07-1.40) extremes. Lastly, only younger fathers were at increased risk of having a child with AML (pooled RR = 1.28, 95 % CI 1.04-1.59). In conclusion, maternal and paternal age represents a meaningful risk factor for childhood leukemia, albeit of different effect size by leukemia subtype. Genetic and socio-economic factors may underlie the observed associations. Well-adjusted studies, scheduled by large consortia, are anticipated to satisfactorily address methodological issues, whereas the potential underlying genetic mechanisms should be elucidated by basic research studies.

Indexed as

Maternal AgePaternal AgePrenatal Exposure Delayed EffectsAdolescentChildChild, PreschoolFemaleHumansInfantInfant, NewbornLeukemia, Myeloid, AcuteMaleParentsPrecursor Cell Lymphoblastic Leukemia-LymphomaPregnancyRisk FactorsChildhood leukemiaMeta-analysisMeta-regressionParental ageRisk factor

Identifiers

PMID26537708

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.