ReviewInternational wound journal2016
A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease.
Review in International wound journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The Effect of Photobiomodulation in the Management of Leg Ulcers in Sickle Cell Disease: A Systematic Review.International wound journal · 2026Pooled it
- Brief topical sodium nitrite and its impact on the quality of life in patients with sickle leg ulcers.Medicine · 2018Trial
- Clinical Vignettes Part I.Hematology/oncology clinics of North America · 2022Review
- Prevalence of people with sickle cell disease and leg ulcers in Brazil: Socioeconomic and clinical overview.PloS one · 2022Article
- Leg ulcers in sickle cell disease patients.Jornal vascular brasileiro · 2020Review
- Sickle cell disease clinical phenotypes in Nigeria: A preliminary analysis of the Sickle Pan Africa Research Consortium Nigeria database.Blood cells, molecules & diseases · 2020Article
- [Pain management in sickle cell disease].Schmerz (Berlin, Germany) · 2020Article
- Leg Ulcers in Sickle-Cell Disease: Treatment Update.Advances in wound care · 2020Review
- Use of a National Electronic Health Record Network to Describe Characteristics and Healing Patterns of Sickle Cell Ulcers.Advances in wound care · 2018Article
- Sickle Cell Disease Clinical Trials and Phenotypes.Journal of tropical diseases & public health · 2018Article
- Sickle Cell Anemia and Comorbid Leg Ulcer Treated With Curative Peripheral Blood Stem Cell Transplantation.The international journal of lower extremity wounds · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sickle cell leg ulcers (SCLUs) are a common complication of sickle cell disease (SCD). Patients who develop ulcers appear to have a more severe haemolysis-associated vasculopathy than individuals who do not develop them, and manifest other complications such as priapism and pulmonary hypertension. SCLUs are slow to heal and often recur, affecting both the emotional and physical well-being of patients. Here we summarise what is known about the pathophysiology of SCLUs, describe available treatment options and propose a treatment algorithm.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.