ReviewPflugers Archiv : European journal of physiology2016
Physiological role of aquaporin 5 in salivary glands.
Review in Pflugers Archiv : European journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Protective effects of multi-strain probiotics against polystyrene nanoplastic-induced parotid gland toxicity: role of NRF2/HO-1 and NF-κB pathways.Frontiers in pharmacology · 2026Article
- Applied anatomy and morphology of minor salivary glands in commonly used experimental animals.Scientific reports · 2025Article
- Role of innate immunity and systemic inflammation in cystic fibrosis disease progression.Heliyon · 2023Review
- Ontogenetic development of the water channel protein AQP5 in mouse salivary gland tissue.Cell and tissue research · 2023Article
- Expression of phosphate and calcium transporters and their regulators in parotid glands of mice.Pflugers Archiv : European journal of physiology · 2023Article
- Physiological Cooperation between Aquaporin 5 and TRPV4.International journal of molecular sciences · 2022Review
- Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice.Scientific reports · 2022Article
- Apigenin, a Single Active Component of Herbal Extract, Alleviates XerostomiaFrontiers in pharmacology · 2022Article
- Ezrin Regulates CaInternational journal of molecular sciences · 2021Article
- Differential activation of CaNPJ Regenerative medicine · 2021Article
- Insulin on changes in expressions of aquaporin-1, aquaporin-5, and aquaporin-8 in submandibular salivary glands of rats with Streptozotocin-induced diabetes.International journal of clinical and experimental pathology · 2021Article
- Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions.International journal of molecular sciences · 2020Review
- Evaluation of Aquaporins 1 and 5 Expression in Rat Parotid Glands After Volumetric Modulated Arc Radiotherapy and Use of Low-Level Laser Therapy at Different Times.Journal of lasers in medical sciences · 2020Article
- Carbonic anhydrase 12 mutation modulates membrane stability and volume regulation of aquaporin 5.Journal of enzyme inhibition and medicinal chemistry · 2019Article
- Significance of transient receptor potential vanilloid 4 and aquaporin 5 co-expression in the rat uterus at term.Heliyon · 2019Article
- Involvement of Aquaporins in the Pathogenesis, Diagnosis and Treatment of Sjögren's Syndrome.International journal of molecular sciences · 2018Review
- Free and bound cortisol in plasma and saliva during ACTH challenge in dairy cows and horses.Journal of animal science · 2018Article
- Defense Mechanisms Against Acid Exposure by Dental Enamel Formation, Saliva and Pancreatic Juice Production.Current pharmaceutical design · 2018Review
- Article
- Aquaporins in Salivary Glands: From Basic Research to Clinical Applications.International journal of molecular sciences · 2016Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regarding the 13 known mammalian aquaporins (AQPs), their functions in their expressing tissues, effects of their mutation/polymorphisms in humans, and effects of knockout of their genes are summarized in this review article. The roles of AQP5, an exocrine gland-type water channel, in the salivary gland under normal and pathophysiological conditions are reviewed in detail. First, the involvement of AQP5 in water secretion from acinar cells was demonstrated by measuring volume changes of acini/acinar cells, as well as activation energy (E a) in transepithelial water movement by NMR spectrometry, and a functional linkage between AQP5 and TRPV4 was suggested. Next, involvement of the parasympathetic nervous system on the AQP5 levels in the acinar cells of the submandibular and that of a β-adrenergic agonist on those in the parotid gland are described. That is, chorda tympani denervation induces autophagy of the submandibular gland, causing AQP5 degradation/metabolism, whereas isoproterenol, a β-adrenergic agonist, causes first an increase then decrease in AQP5 levels in the parotid gland, which action is coupled with the secretory-restoration cycle of amylase-containing secretory granules. The PG also responded to endotoxin, a lipopolysaccharide that activates NF-κB and MAPK pathways. Elevated NF-κB and AP-1 (c-Fos/c-Jun) form a complex that can bind to the NF-κB-responsive element on the AQP5 promoter and thus potentially downregulate AQP5 transcription. Salivary gland pathologies and conditions involving AQP5 and possible treatments are described as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.