ReviewQuarterly reviews of biophysics2015
Acceleration of reaction in charged microdroplets.
Review in Quarterly reviews of biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
76 citing papers in PubMed.
- One-Step, High-Yield Deconstruction of Kraft Lignin Into a Redox-Active Small Molecule Using Sonicated Emulsive Water Microdroplets.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Rapid spontaneous generation of organosulfur from inorganic sulfur in atmospheric microdroplets.Nature communications · 2026Article
- Accelerated Chemistry in Microdroplets.Accounts of chemical research · 2026Article
- Surface tension measurements reveal charge-driven surfactant depletion in microdroplets approaching the Rayleigh limit.Chemical science · 2026Article
- Ultrafast Postcolumn Microdroplet Derivatization of Nucleobases for Enhanced Online Detection, Characterization, and Quantification of Nucleic Acid Modifications Using LC-MSAnalytical chemistry · 2026Article
- Enhancement of Esterification Reaction Rates in Solvent-Free Aerosol Droplets.Journal of the American Chemical Society · 2026Article
- Capture and identification of the electrogenerated picosecond intermediates by mass spectrometry.Fundamental research · 2026Article
- Electric fields at hydrophobic water interfaces: spectroscopic evidence, physical origin, and implications on reactivity.Chemical Society reviews · 2026Review
- Liquid Crystal-Driven Chemical Feeding Accelerates Condensation Reactions in Droplet Microreactors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ester Formation in Alcohol Microdroplet Sprays: Enhanced Reactivity of CThe journal of physical chemistry. A · 2025Article
- Seeing the unseen: spatio-temporal visualization of reactive carbocation intermediates in electrolytic cells.Chemical science · 2025Article
- Photodissociation Dynamics in (NThe journal of physical chemistry. A · 2025Article
- Diversity of Effects of Mechanical Influences on Living Systems and Aqueous Solutions.International journal of molecular sciences · 2025Review
- Accelerated Synthesis of Pyrazoles Mediated by Water Microdroplets.ACS sustainable chemistry & engineering · 2025Article
- Serine Octamer Clusters Direct the Chirality of Peptides Formed in Water Microdroplets.The journal of physical chemistry. A · 2025Article
- Spontaneous Oxidation of Nitrous Acid to Nitric Acid in Supermicron Aqueous Droplets Is Acid-Accelerated.ACS earth & space chemistry · 2025Article
- A Source of the MysteriousACS central science · 2025Article
- Deciphering the mechanism of hydrogen peroxide formation in ultrasound-mediated water-in-oil microdroplets.Chemical science · 2025Article
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16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Using high-resolution mass spectrometry, we have studied the synthesis of isoquinoline in a charged electrospray droplet and the complexation between cytochrome c and maltose in a fused droplet to investigate the feasibility of droplets to drive reactions (both covalent and noncovalent interactions) at a faster rate than that observed in conventional bulk solution. In both the cases we found marked acceleration of reaction, by a factor of a million or more in the former and a factor of a thousand or more in the latter. We believe that carrying out reactions in microdroplets (about 1-15 μm in diameter corresponding to 0·5 pl - 2 nl) is a general method for increasing reaction rates. The mechanism is not presently established but droplet evaporation and droplet confinement of reagents appear to be two important factors among others. In the case of fused water droplets, evaporation has been shown to be almost negligible during the flight time from where droplet fusion occurs and the droplets enter the heated capillary inlet of the mass spectrometer. This suggests that (1) evaporation is not responsible for the acceleration process in aqueous droplet fusion and (2) the droplet-air interface may play a significant role in accelerating the reaction. We argue that this 'microdroplet chemistry' could be a remarkable alternative to accelerate slow and difficult reactions, and in conjunction with mass spectrometry, it may provide a new arena to study chemical and biochemical reactions in a confined environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.