SynthesisClinical child and family psychology review2015
Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.
Synthesis in Clinical child and family psychology review, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Probing the genomic landscape of human sexuality: a critical systematic review of the literature.Frontiers in genetics · 2023Pooled it
- Pooled it
- Childhood violence exposure and externalizing behaviors: A systematic review of the role of physiological biomarkers.Psychoneuroendocrinology · 2022Pooled it
- Childhood Trauma and Aggression: The Role of Epistemic Trust.Journal of child & adolescent trauma · 2026Article
- Requiem for Many Dreams? Comorbid Substance Use and Disruptive Behaviour Disorders in Adolescents.Indian journal of psychological medicine · 2026Article
- Risk Modeling and Association Pathways Integrating Psychosocial Factors for Drug Misuse in Adolescents and Young Adults: A Machine Learning Approach.European addiction research · 2026Article
- Heterogeneity of early-onset conduct problems: assessing different profiles, predictors and outcomes across childhood.Child and adolescent psychiatry and mental health · 2025Article
- Article
- Associations of the serotonin transporter gene polymorphism, 5-HTTLPR, and adverse life events with late life depression in the elderly Lithuanian population.Scientific reports · 2023Article
- Dietary Supplementation with Milk Lipids Leads to Suppression of Developmental and Behavioral Phenotypes of Hyperexcitable Drosophila Mutants.Neuroscience · 2023Article
- Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort.Neuroscience applied · 2023Article
- Parental rejection in early adolescence predicts a persistent ADHD symptom trajectory across adolescence.European child & adolescent psychiatry · 2023Article
- Examining how and why polygenic dopamine composite levels moderate adolescents' vulnerability to peer victimization.Child and adolescent psychiatry and mental health · 2022Article
- Antipsychotics in the Management of Disruptive Behavior Disorders in Children and Adolescents: An Update and Critical Review.Biomedicines · 2022Review
- Longitudinal Influences of DRD4 Polymorphism and Early Maternal Caregiving on Personality Development and Problem Behavior in Middle Childhood and Adolescence.Frontiers in human neuroscience · 2022Article
- Serotonergic sensitivity alleles moderate relations between attachment security at age three and socioemotional competence at age five.Developmental psychobiology · 2021Article
- Early childhood psychosocial family risks and cumulative dopaminergic sensitizing score: Links to behavior problems in U.S. 9-year-olds.Journal of affective disorders · 2021Article
- The gray matter volume of the temporoparietal junction varies across cultures: a moderating role of the dopamine D4 receptor gene (DRD4).Social cognitive and affective neuroscience · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last decade, several candidate genes (i.e., MAOA, DRD4, DRD2, DAT1, 5-HTTLPR, and COMT) have been extensively studied as potential moderators of the detrimental effects of postnatal family adversity on child externalizing behaviors, such as aggression and conduct disorder. Many studies on such candidate gene by environment interactions (i.e., cG × E) have been published, and the first part of this paper offers a systematic review and integration of their findings (n = 53). The overview shows a set of heterogeneous findings. However, because of large differences between studies in terms of sample composition, conceptualizations, and power, it is difficult to determine if different findings indeed illustrate inconsistent cG × E findings or if findings are simply incomparable. In the second part of the paper, therefore, we argue that one way to help resolve this problem is the development of theory-driven a priori hypotheses on which biopsychosocial mechanisms might underlie cG × E. Such a theoretically based approach can help us specify our research strategies, create more comparable findings, and help us interpret different findings between studies. In accordance, we describe three possible explanatory mechanisms, based on extant literature on the concepts of (1) emotional reactivity, (2) reward sensitivity, and (3) punishment sensitivity. For each mechanism, we discuss the link between the putative mechanism and externalizing behaviors, the genetic polymorphism, and family adversity. Possible research strategies to test these mechanisms, and implications for interventions, are discussed.
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