ArticleJournal of Zhejiang University. Science. B2015
Repair of articular cartilage defects in rabbits through tissue-engineered cartilage constructed with chitosan hydrogel and chondrocytes.
Article in Journal of Zhejiang University. Science. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Smart functionalized cartilage repair microspheres: Concepts and applications.Materials today. Bio · 2026Review
- Recent Advances and Applications of Chitin and Chitosan Hydrogel Scaffolds in Tissue Engineering.Gels (Basel, Switzerland) · 2026Review
- The role of costal cartilage in musculoskeletal regeneration: A systematic review.Journal of experimental orthopaedics · 2026Review
- Advanced Hydrogels in Fibrocartilage Regeneration of the Glenoid Labrum.Gels (Basel, Switzerland) · 2025Review
- Hydrogel-Enhanced Autologous Chondrocyte Implantation for Cartilage Regeneration-An Update on Preclinical Studies.Bioengineering (Basel, Switzerland) · 2024Review
- A bioactive composite scaffold enhances osteochondral repair by using thermosensitive chitosan hydrogel and endothelial lineage cell-derived chondrogenic cell.Materials today. Bio · 2024Article
- A Review of Cartilage Defect Treatments Using Chitosan Hydrogels in Experimental Animal Models.Current pharmaceutical biotechnology · 2024Review
- Suppressing Chondrocyte Hypertrophy to Build Better Cartilage.Bioengineering (Basel, Switzerland) · 2023Review
- Current Understanding of Hydrogel for Drug Release and Tissue Engineering.Gels (Basel, Switzerland) · 2022Review
- General Characteristics, Biomedical and Dental Application, and Usage of Chitosan in the Treatment of Temporomandibular Joint Disorders: A Narrative Review.Pharmaceutics · 2022Review
- Anti-hypertrophic effect of synovium-derived stromal cells on costal chondrocytes promotes cartilage repairs.Journal of orthopaedic translation · 2022Article
- Cartilage Tissue Engineering Approaches Need to Assess Fibrocartilage When Hydrogel Constructs Are Mechanically Loaded.Frontiers in bioengineering and biotechnology · 2021Review
- Exquisite design of injectable Hydrogels in Cartilage Repair.Theranostics · 2020Review
- Construction and analysis of finite element model of defected articular cartilage.Saudi journal of biological sciences · 2020Article
- Article
- [Preparation and evaluation of carboxymethyl chitosan/sodium alginate hydrogel for cartilage tissue engineering].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019Article
- Review
- Current and novel injectable hydrogels to treat focal chondral lesions: Properties and applicability.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Review
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Authors and funding
9 authors.
Funding
Abstract
objectiveIn our previous work, we prepared a type of chitosan hydrogel with excellent biocompatibility. In this study, tissue-engineered cartilage constructed with this chitosan hydrogel and costal chondrocytes was used to repair the articular cartilage defects.
methodsChitosan hydrogels were prepared with a crosslinker formed by combining 1,6-diisocyanatohexane and polyethylene glycol. Chitosan hydrogel scaffold was seeded with rabbit chondrocytes that had been cultured for one week in vitro to form the preliminary tissue-engineered cartilage. This preliminary tissue-engineered cartilage was then transplanted into the defective rabbit articular cartilage. There were three treatment groups: the experimental group received preliminary tissue-engineered cartilage; the blank group received pure chitosan hydrogels; and, the control group had received no implantation. The knee joints were harvested at predetermined time. The repaired cartilage was analyzed through gross morphology, histologically and immunohistochemically. The repairs were scored according to the international cartilage repair society (ICRS) standard.
resultsThe gross morphology results suggested that the defects were repaired completely in the experimental group after twelve weeks. The regenerated tissue connected closely with subchondral bone and the boundary with normal tissue was fuzzy. The cartilage lacuna in the regenerated tissue was similar to normal cartilage lacuna. The results of ICRS gross and histological grading showed that there were significant differences among the three groups (P<0.05).
conclusionsChondrocytes implanted in the scaffold can adhere, proliferate, and secrete extracellular matrix. The novel tissue-engineered cartilage constructed in our research can completely repair the structure of damaged articular cartilage.
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