Evidence map›Paper›PMID 26537198›Full record

Trial reportObesity (Silver Spring, Md.)2015

Dose response of exercise training following roux-en-Y gastric bypass surgery: A randomized trial.

Tracey L Woodlief, Elvis A Carnero, Robert A Standley, Giovanna Distefano, Steve J Anthony, Gabe S Dubis, John M Jakicic, Joseph A Houmard, Paul M Coen, Bret H Goodpaster

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04151836 (Effect of Exercise Intervention on Body Composition and Quality of Life in Post-bariatric Surgery Patients), which is not on this map. Cited by 28 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 8 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04151836 nacompletednot on this mapstarted 2020, after this paper: background citation

Effect of Exercise Intervention on Body Composition and Quality of Life in Post-bariatric Surgery Patients

TypeinterventionalSponsorChang Gung Memorial HospitalRan2020 to 2021Enrolled85ConditionsExerciseArmsExercise education
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 8 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Expert-based physical activity guidelines for metabolic and bariatric surgery patients: a systematic review of randomized controlled trials.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025
    Pooled it
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  5. Effect of exercise training before and after bariatric surgery: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tracey L WoodliefTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida, USA.
Elvis A CarneroTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida, USA.
Robert A StandleyTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida, USA.
Giovanna DistefanoTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida, USA.
Steve J AnthonyDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gabe S DubisDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John M JakicicDepartment of Health and Physical Activity, University of Pittsburgh, Pennsylvania, USA.
Joseph A HoumardDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Paul M CoenTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida, USA.
Bret H GoodpasterTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida, USA.
University of Pittsburgh · USTranslational Research Institute for Metabolism and Diabetes · US

Funding

WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2M
Physical Activity Following Surgery-Induced Weight LossR01DK078192 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOODPASTER, BRET H · 2008 to 2012
$3.0M
NCRR NIH HHS M01 RR000056NCRR NIH HHS M01RR00056NIDDK NIH HHS R01 DK078192NIDDK NIH HHS R01DK078192NIDDK NIH HHS R01DK078192-02S1
6 · The paper itself

Abstract

objectiveRoux-en-Y gastric bypass (RYGB) surgery can cause profound weight loss and improve overall cardiometabolic risk factors. Exercise (EX) training following RYGB can provide additional improvements in insulin sensitivity (SI ) and cardiorespiratory fitness. However, it remains unknown whether a specific amount of EX post-RYGB is required to achieve additional benefits.

methodsWe performed a post hoc analysis of participants who were randomized into either a 6-month structured EX program or a health education control (CON). The EX group (n = 56) was divided into tertiles according to the amount of weekly exercise performed, compared with CON (n = 42): low-EX = 54 ± 8; middle-EX = 129 ± 4; and high-EX = 286 ± 40 min per week.

resultsThe high-EX lost a significantly greater amount of body weight, total fat mass, and abdominal deep subcutaneous abdominal fat compared with CON (P < 0.005). SI improved to a greater extent in both the middle-EX and high-EX compared with CON (P < 0.04). Physical fitness (VO2 max) significantly improved in the high-EX (9.3% ± 4.2%) compared with CON (-6.0 ± 2.4%) (P < 0.001). Skeletal muscle mitochondrial State 4 (P < 0.002) and 3 (P < 0.04) respiration was significantly higher in the high-EX compared with CON.

conclusionsA modest volume of structured exercise provides additional improvements in insulin sensitivity following RYGB, but higher volumes of exercise are required to induce additional weight loss, changes in body composition, and improvements in cardiorespiratory fitness and skeletal muscle mitochondrial capacity.

Indexed as

AdultBody CompositionBody WeightCardiovascular DiseasesExerciseExercise TherapyFemaleGastric BypassHumansInsulin ResistanceMaleMiddle AgedObesityPhysical FitnessPostoperative PeriodRisk Factors

Identifiers

PMID26537198
PMCPMC5480215
OpenAlexW2171834252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.