ArticlePloS one2015
Role of Tellurite Resistance Operon in Filamentous Growth of Yersinia pestis in Macrophages.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 31 citations in OpenAlex.
- Genomic Characteristics of a Multidrug-Resistant Extraintestinal PathogenicMicroorganisms · 2026Article
- The tellurite resistance gene cluster of pathogenic bacteria and its effect on oxidative stress response.Folia microbiologica · 2024Article
- Characterization of the Tellurite-Resistance Properties and Identification of the Core Function Genes for Tellurite Resistance inMicroorganisms · 2022Article
- Tellurium: A Rare Element with Influence on Prokaryotic and Eukaryotic Biological Systems.International journal of molecular sciences · 2021Review
- A plasmid locus associated with Klebsiella clinical infections encodes a microbiome-dependent gut fitness factor.PLoS pathogens · 2021Article
- Response ofPeerJ · 2021Article
- Diversity of the Tellurite Resistance Gene Operon inFrontiers in microbiology · 2021Article
- Genomic analyses of Burkholderia cenocepacia reveal multiple species with differential host-adaptation to plants and humans.BMC genomics · 2019Article
- Genomic analysis of a novel Rhodococcus (Prescottella) equi isolate from a bovine host.Archives of microbiology · 2019Article
- Draft Genome Sequence of Escherichia coli KL53.Genome announcements · 2018Article
- Thymus vulgaris L. and thymol assist murine macrophages (RAW 264.7) in the control of in vitro infections by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans.Immunologic research · 2017Article
- Evolutionary study of Yersinia genomes deciphers emergence of human pathogenic species.Scientific reports · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundYersinia pestis initiates infection by parasitism of host macrophages. In response to macrophage infections, intracellular Y. pestis can assume a filamentous cellular morphology which may mediate resistance to host cell innate immune responses. We previously observed the expression of Y. pestis tellurite resistance proteins TerD and TerE from the terZABCDE operon during macrophage infections. Others have observed a filamentous response associated with expression of tellurite resistance operon in Escherichia coli exposed to tellurite. Therefore, in this study we examine the potential role of Y. pestis tellurite resistance operon in filamentous cellular morphology during macrophage infections. PRINCIPAL
findingsIn vitro treatment of Y. pestis culture with sodium tellurite (Na2TeO3) caused the bacterial cells to assume a filamentous phenotype similar to the filamentous phenotype observed during macrophage infections. A deletion mutant for genes terZAB abolished the filamentous morphologic response to tellurite exposure or intracellular parasitism, but without affecting tellurite resistance. However, a terZABCDE deletion mutant abolished both filamentous morphologic response and tellurite resistance. Complementation of the terZABCDE deletion mutant with terCDE, but not terZAB, partially restored tellurite resistance. When the terZABCDE deletion mutant was complemented with terZAB or terCDE, Y. pestis exhibited filamentous morphology during macrophage infections as well as while these complemented genes were being expressed under an in vitro condition. Further in E. coli, expression of Y. pestis terZAB, but not terCDE, conferred a filamentous phenotype.
conclusionsThese findings support the role of Y. pestis terZAB mediation of the filamentous response phenotype; whereas, terCDE confers tellurite resistance. Although the beneficial role of filamentous morphological responses by Y. pestis during macrophage infections is yet to be fully defined, it may be a bacterial adaptive strategy to macrophage associated stresses.
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