Evidence map›Paper›PMID 26536598›Full record

ArticlePloS one2015

Mapping Individual Brain Networks Using Statistical Similarity in Regional Morphology from MRI.

Xiang-zhen Kong, Zhaoguo Liu, Lijie Huang, Xu Wang, Zetian Yang, Guangfu Zhou, Zonglei Zhen, Jia Liu

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05818410 (Human-Prosthetic Interaction), which is not on this map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05818410 narecruitingnot on this mapstarted 2024, after this paper: background citation

Human-Prosthetic Interaction: Brain & Technology After Lower-Limb Loss

TypeinterventionalSponsorVrije Universiteit BrusselRan2024 to 2028Enrolled60ConditionsLower Limb Amputation Below Knee (Injury)ArmsProsthetic device (Lunaris), No prosthetic device, Prosthetic device (Sach foot)
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 124 citations in OpenAlex.

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  10. Review
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  12. Structural MRI of brain similarity networks.Nature reviews. Neuroscience · 2025
    Review
  13. Article
  14. Brain connectome from neuronal morphology.Network neuroscience (Cambridge, Mass.) · 2025
    Article
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiang-zhen KongState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Zhaoguo LiuState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Lijie HuangState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Xu WangState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Zetian YangState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Guangfu ZhouState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Zonglei ZhenState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Jia LiuSchool of Psychology, Beijing Normal University, Beijing, 100875, China.
Beijing Normal University · CNChinese Institute for Brain Research · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Representing brain morphology as a network has the advantage that the regional morphology of 'isolated' structures can be described statistically based on graph theory. However, very few studies have investigated brain morphology from the holistic perspective of complex networks, particularly in individual brains. We proposed a new network framework for individual brain morphology. Technically, in the new network, nodes are defined as regions based on a brain atlas, and edges are estimated using our newly-developed inter-regional relation measure based on regional morphological distributions. This implementation allows nodes in the brain network to be functionally/anatomically homogeneous but different with respect to shape and size. We first demonstrated the new network framework in a healthy sample. Thereafter, we studied the graph-theoretical properties of the networks obtained and compared the results with previous morphological, anatomical, and functional networks. The robustness of the method was assessed via measurement of the reliability of the network metrics using a test-retest dataset. Finally, to illustrate potential applications, the networks were used to measure age-related changes in commonly used network metrics. Results suggest that the proposed method could provide a concise description of brain organization at a network level and be used to investigate interindividual variability in brain morphology from the perspective of complex networks. Furthermore, the method could open a new window into modeling the complexly distributed brain and facilitate the emerging field of human connectomics.

Indexed as

Models, NeurologicalStatistics as TopicAdultBrainBrain MappingComputer SimulationConnectomeFemaleHumansMagnetic Resonance ImagingMiddle AgedNerve NetYoung Adult

Identifiers

PMID26536598
PMCPMC4633111
OpenAlexW2175501639

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.