Evidence map›Paper›PMID 26536383›Full record

ReviewAutism research : official journal of the International Society for Autism Research2016

Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research.

Lindsay M Oberman, Peter G Enticott, Manuel F Casanova, Alexander Rotenberg, Alvaro Pascual-Leone, James T McCracken, TMS in ASD Consensus Group

3 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Autism research : official journal of the International Society for Autism Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 52 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02939560 nacompletednot on this map

Transcranial Magnetic Stimulation for Adults With Autism Spectrum Disorder and Depression

TypeinterventionalSponsorMedical University of South CarolinaRan2016 to 2018Enrolled13ConditionsAutism Spectrum Disorder, Depression, Depressive Disorder, Major Depressive DisorderArmsNeuroStar® TMS device (Neuronetics, Atlanta, GA)
NCT05235919 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

Repetitive Transcranial Magnetic Stimulation to Promote Helpful Self-regulatory Behaviour in Children and Youth With Autism Spectrum Disorder

TypeinterventionalSponsorHolland Bloorview Kids Rehabilitation HospitalRan2022 to 2025Enrolled50ConditionsAutism Spectrum Disorder, Self-Regulation, EmotionArmsrepetitive transcranial magnetic stimulation (rTMS), Sham stimulation
NCT06069323 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.

TypeinterventionalSponsorOspedali Riuniti di FoggiaRan2023 to 2026Enrolled80ConditionsAutism Spectrum Disorder, ADHD, Neurodevelopmental DisordersArmsrepetitive Transcranial Magnetic Stimulation
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Neuromodulation and the Gut-Brain Axis: Therapeutic Mechanisms and Implications for Gastrointestinal and Neurological Disorders.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
  16. Article
  17. Review
  18. Review
  19. The use of noninvasive brain stimulation techniques in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 2 countries.

Lindsay M ObermanNeuroplasticity and Autism Spectrum Disorder Program and Department of Psychiatry and Human Behavior, E.P. Bradley Hospital and Warren Alpert Medical School, Brown University, Providence, Rhode, Island.
Peter G EnticottCognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, Victoria, Australia.
Manuel F CasanovaDepartment of Psychiatry and Behavioral Science, University of Louisville, Louisville, Kentucky.
Alexander RotenbergNeuromodulation Program, Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Alvaro Pascual-LeoneNeuromodulation Program, Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
James T McCrackenDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California.
TMS in ASD Consensus Group
Boston Children's Hospital · USBradley Hospital · USDeakin University · AUHarvard University · USJohns Hopkins University · USNeurobehavioral Systems · USUniversity of Louisville · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Transcranial Direct Current Stimulation and Robotic Training in Chronic StrokeR01HD069776 · NICHD · WINIFRED MASTERSON BURKE MED RES INST · PI EDWARDS, DYLAN JAMES · 2012 to 2016
$3.2M
Cortical Plasticity in Autism Spectrum DisordersR01MH100186 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROTENBERG, ALEXANDER · 2014 to 2018
$2.2M
Cortical connectivity, physiology, and response to stimulation in human epilepsyR01NS073601 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHANG, BERNARD S. · 2011 to 2015
$1.9M
Harvard Clinical and Translational Science Center (KL2)KL2TR000168 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$965k
Role of functional brain connectivity on efficacy of TMS for depressionR21MH099196 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$491k
Cortical plasticity in type II diabetes mellitusR21NS082870 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$490k
Transcranial Stimulation in Spino-Cerebellar AtaxiaR21NS085491 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$469k
NCATS NIH HHS KL2 TR000168NCRR NIH HHS UL1 RR025758NICHD NIH HHS R01 HD069776NIMH NIH HHS R01 MH100186NIMH NIH HHS R21 MH099196NINDS NIH HHS R01 NS073601NINDS NIH HHS R21 NS082870NINDS NIH HHS R21 NS085491
6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is a behaviorally defined complex neurodevelopmental syndrome characterized by impairments in social communication, by the presence of restricted and repetitive behaviors, interests and activities, and by abnormalities in sensory reactivity. Transcranial magnetic stimulation (TMS) is a promising, emerging tool for the study and potential treatment of ASD. Recent studies suggest that TMS measures provide rapid and noninvasive pathophysiological ASD biomarkers. Furthermore, repetitive TMS (rTMS) may represent a novel treatment strategy for reducing some of the core and associated ASD symptoms. However, the available literature on the TMS use in ASD is preliminary, composed of studies with methodological limitations. Thus, off-label clinical rTMS use for therapeutic interventions in ASD without an investigational device exemption and outside of an IRB approved research trial is premature pending further, adequately powered and controlled trials. Leaders in this field have gathered annually for a two-day conference (prior to the 2014 and 2015 International Meeting for Autism Research, IMFAR) to share recent progress, promote collaboration across laboratories, and establish consensus on protocols. Here we review the literature in the use of TMS in ASD in the context of the unique challenges required for the study and exploration of treatment strategies in this population. We also suggest future directions for this field of investigations. While its true potential in ASD has yet to be delineated, TMS represents an innovative research tool and a novel, possibly transformative approach to the treatment of neurodevelopmental disorders.

Indexed as

Autism Spectrum DisorderHumansTranscranial Magnetic Stimulationautism spectrum disorderconsensusreviewtranscranial magnetic stimulationtreatment

Identifiers

PMID26536383
PMCPMC4956084
OpenAlexW2114749506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.