Evidence map›Paper›PMID 26536378›Full record

ArticleStructure (London, England : 1993)2015

A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1.

Richard A Kahn, David G Lambright

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Structure (London, England : 1993), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Richard A KahnDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: rkahn@emory.edu.
David G LambrightProgram in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: david.lambright@umassmed.edu.
Emory University · USUniversity of Massachusetts Chan Medical School · US

Funding

STRUCTURAL BASIS OF G PROTEIN MEDIATED SIGNALINGR01GM056324 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LAMBRIGHT, DAVID G · 1998 to 2018
$6.2M
The Regulation and Cellular Activities of the ARL2 GTPaseR01GM090158 · NIGMS · EMORY UNIVERSITY · PI KAHN, RICHARD A · 2010 to 2017
$2.5M
Biology of the ARL13B GTPaseR01GM110663 · NIGMS · EMORY UNIVERSITY · PI CASPARY, TAMARA J., KAHN, RICHARD A · 2014 to 2017
$1.7M
NIGMS NIH HHS R01 GM056324NIGMS NIH HHS R01-GM056324NIGMS NIH HHS R01 GM090158NIGMS NIH HHS R01-GM090158NIGMS NIH HHS R01-GM110663
6 · The paper itself

Abstract

In this issue of Structure, Jian et al. (2015) report the crystal structures of the apo- and dibutyryl-PI(4,5)P2 bound forms of the PH domain from the ARF GAP, ASAP1. This PH domain has two anionic phospholipid binding sites proposed to work in concert to regulate ASAP1 GAP activity.

Indexed as

Models, MolecularAdaptor Proteins, Signal TransducingBinding SitesPhospholipidsProtein BindingProtein Structure, TertiaryAdaptor Proteins, Signal TransducingPhospholipids

Identifiers

PMID26536378
OpenAlexW1958347519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.