Evidence map›Paper›PMID 26536374›Full record

ArticleJournal of the American Chemical Society2015

Remote Oxidation of Aliphatic C-H Bonds in Nitrogen-Containing Molecules.

Jennifer M Howell, Kaibo Feng, Joseph R Clark, Louis J Trzepkowski, M Christina White

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Article
  2. Radical Sampling Enabled Saturated N-Heterocycle Cyclization.Journal of the American Chemical Society · 2026
    Article
  3. Article
  4. Article
  5. Late-Stage Oxidation of C(spAngewandte Chemie (International ed. in English) · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Highly Selective C(spJournal of the American Chemical Society · 2023
    Article
  12. A preparative small-molecule mimic of liver CYP450 enzymes in the aliphatic C-H oxidation of carbocyclicProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Late-Stage Intermolecular Allylic C-H Amination.Journal of the American Chemical Society · 2021
    Article
  20. Practical and Regioselective Synthesis of C-4-Alkylated Pyridines.Journal of the American Chemical Society · 2021
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jennifer M Howell *Roger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.
Kaibo Feng *Roger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.
Joseph R ClarkRoger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.
Louis J TrzepkowskiRoger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.
M Christina WhiteRoger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.

Funding

Synthetic C-H Oxidations and Functionalizations with Sustainable Metal CatalystsR01GM112492 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WHITE, MARIA · 2014 to 2016
$838k
NIGMS NIH HHS GM112492NIGMS NIH HHS R01 GM112492
6 · The paper itself

Abstract

Nitrogen heterocycles are ubiquitous in natural products and pharmaceuticals. Herein, we disclose a nitrogen complexation strategy that employs a strong Brønsted acid (HBF4) or an azaphilic Lewis acid (BF3) to enable remote, non-directed C(sp(3))-H oxidations of tertiary, secondary, and primary amine- and pyridine-containing molecules with tunable iron catalysts. Imides resist oxidation and promote remote functionalization.

Indexed as

CarbonHydrogenNitrogenOxidation-ReductionCarbonHydrogenNitrogen

Identifiers

PMID26536374
PMCPMC4924472

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.