ArticleAnesthesiology2016
Visualizing the Propagation of Acute Lung Injury.
Article in Anesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- The lung in acute respiratory failure: insights from synchrotron radiation imaging.Intensive care medicine experimental · 2026Review
- Mechanical Power and Driving Pressure: Mechanisms of Lung Injury, Markers of Pathophysiology, or Therapeutic Targets?Journal of clinical medicine · 2025Article
- Ventilator-induced lung injury in rat models: are they all equal in the race?Laboratory animal research · 2025Review
- Time-Controlled Adaptive Ventilation (TCAV): a personalized strategy for lung protection.Respiratory research · 2024Review
- First Stabilize and then Gradually Recruit: A Paradigm Shift in Protective Mechanical Ventilation for Acute Lung Injury.Journal of clinical medicine · 2023Review
- Ratchet recruitment in the acute respiratory distress syndrome: lessons from the newborn cry.Frontiers in physiology · 2023Article
- Unshrinking the baby lung to calm the VILI vortex.Critical care (London, England) · 2022Review
- Imatinib alleviates lung injury and prolongs survival in ventilated rats.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Imaging atelectrauma in Ventilator-Induced Lung Injury using 4D X-ray microscopy.Scientific reports · 2021Article
- Pulmonary Interstitial Matrix and Lung Fluid Balance From Normal to the Acutely Injured Lung.Frontiers in physiology · 2021Review
- Use of Organ Dysfunction as a Primary Outcome Variable Following Cecal Ligation and Puncture: Recommendations for Future Studies.Shock (Augusta, Ga.) · 2020Article
- Multi-resolution convolutional neural networks for fully automated segmentation of acutely injured lungs in multiple species.Medical image analysis · 2020Article
- Prevention and treatment of acute lung injury with time-controlled adaptive ventilation: physiologically informed modification of airway pressure release ventilation.Annals of intensive care · 2020Review
- A Physiologically Informed Strategy to Effectively Open, Stabilize, and Protect the Acutely Injured Lung.Frontiers in physiology · 2020Review
- Metabolic Imaging and Biological Assessment: Platforms to Evaluate Acute Lung Injury and Inflammation.Frontiers in physiology · 2020Review
- Mechanical Ventilation Lessons Learned From Alveolar Micromechanics.Frontiers in physiology · 2020Review
- Lessons learned in acute respiratory distress syndrome from the animal laboratory.Annals of translational medicine · 2019Review
- Imaging the Injured Lung: Mechanisms of Action and Clinical Use.Anesthesiology · 2019Review
- Unstable Inflation Causing Injury. Insight from Prone Position and Paired Computed Tomography Scans.American journal of respiratory and critical care medicine · 2018Article
- In vivo imaging of the progression of acute lung injury using hyperpolarized [1-Magnetic resonance in medicine · 2017Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 3 countries.
Funding
Abstract
backgroundMechanical ventilation worsens acute respiratory distress syndrome, but this secondary "ventilator-associated" injury is variable and difficult to predict. The authors aimed to visualize the propagation of such ventilator-induced injury, in the presence (and absence) of a primary underlying lung injury, and to determine the predictors of propagation.
methodsAnesthetized rats (n = 20) received acid aspiration (hydrochloric acid) followed by ventilation with moderate tidal volume (V(T)). In animals surviving ventilation for at least 2 h, propagation of injury was quantified by using serial computed tomography. Baseline lung status was assessed by oxygenation, lung weight, and lung strain (V(T)/expiratory lung volume). Separate groups of rats without hydrochloric acid aspiration were ventilated with large (n = 10) or moderate (n = 6) V(T).
resultsIn 15 rats surviving longer than 2 h, computed tomography opacities spread outward from the initial site of injury. Propagation was associated with higher baseline strain (propagation vs. no propagation [mean ± SD]: 1.52 ± 0.13 vs. 1.16 ± 0.20, P < 0.01) but similar oxygenation and lung weight. Propagation did not occur where baseline strain was less than 1.29. In healthy animals, large V(T) caused injury that was propagated inward from the lung periphery; in the absence of preexisting injury, propagation did not occur where strain was less than 2.0.
conclusionsCompared with healthy lungs, underlying injury causes propagation to occur at a lower strain threshold and it originates at the site of injury; this suggests that tissue around the primary lesion is more sensitive. Understanding how injury is propagated may ultimately facilitate a more individualized monitoring or management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.