Evidence map›Paper›PMID 26536290›Full record

ArticleALTEX2015

Quality assurance of metabolomics.

Mounir Bouhifd, Richard Beger, Thomas Flynn, Lining Guo, Georgina Harris, Helena Hogberg, Rima Kaddurah-Daouk, Hennicke Kamp, Andre Kleensang, Alexandra Maertens and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ALTEX, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Towards quality assurance and quality control in untargeted metabolomics studies.Metabolomics : Official journal of the Metabolomic Society · 2019
    Article
  17. Current Challenges in Plant Eco-Metabolomics.International journal of molecular sciences · 2018
    Review
  18. Article
  19. Article
  20. FutureTox III: Bridges for Translation.Toxicological sciences : an official journal of the Society of Toxicology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mounir BouhifdJohns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Richard BegerUS Food and Drug Administration, National Center for Toxicological Research, Division of Systems Biology, Jefferson, AR, USA.
Thomas FlynnUS Food and Drug Administration, Center for Food Safety and Applied Nutrition, Laurel, MD, USA.
Lining GuoMetabolon, Inc., Durham, NC, USA;
Georgina HarrisJohns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Helena HogbergJohns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Rima Kaddurah-DaoukDepartment of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences, Duke University, Durham, NC, USA.
Hennicke KampExperimental Toxicology and Ecology, BASF SE, Ludwigshafen am Rhein, Germany.
Andre KleensangJohns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Alexandra MaertensJohns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Shelly Odwin-DaCostaJohns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
David PamiesJohns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Donald RobertsonBristol-Myers Squibb Pharmaceutical Co., Princeton, NJ, USA.
Lena SmirnovaJohns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Jinchun SunUS Food and Drug Administration, National Center for Toxicological Research, Division of Systems Biology, Jefferson, AR, USA.
Liang ZhaoJohns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.
Thomas HartungJohns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.

Funding

Mapping the Human Toxome by Systems ToxicologyR01ES020750 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HARTUNG, THOMAS · 2011 to 2015
$6.0M
NIEHS NIH HHS R01 ES020750NIEHS NIH HHS R01ES020750
6 · The paper itself

Abstract

Metabolomics promises a holistic phenotypic characterization of biological responses to toxicants. This technology is based on advanced chemical analytical tools with reasonable throughput, including mass-spectroscopy and NMR. Quality assurance, however - from experimental design, sample preparation, metabolite identification, to bioinformatics data-mining - is urgently needed to assure both quality of metabolomics data and reproducibility of biological models. In contrast to microarray-based transcriptomics, where consensus on quality assurance and reporting standards has been fostered over the last two decades, quality assurance of metabolomics is only now emerging. Regulatory use in safety sciences, and even proper scientific use of these technologies, demand quality assurance. In an effort to promote this discussion, an expert workshop discussed the quality assurance needs of metabolomics. The goals for this workshop were 1) to consider the challenges associated with metabolomics as an emerging science, with an emphasis on its application in toxicology and 2) to identify the key issues to be addressed in order to establish and implement quality assurance procedures in metabolomics-based toxicology. Consensus has still to be achieved regarding best practices to make sure sound, useful, and relevant information is derived from these new tools.

Indexed as

Quality ControlAnimalsAnimal Testing AlternativesMetabolomicsModels, Biologicalhuman toxomemetabolomicsquality assurancetoxicometabolomics

Identifiers

PMID26536290
PMCPMC5578451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.